Inhibition of transcriptional regulator Yin-Yang-1 by association with c-myc

A. Shrivastava; S. Saleque; G. V. Kalpana; S. Artandi; S. P. Goff; K. Calame

doi:10.1126/science.8266081

Inhibition of transcriptional regulator Yin-Yang-1 by association with c-myc

A. Shrivastava
, S. Saleque
, G. V. Kalpana
, S. Artandi
, S. P. Goff
, K. Calame

Research output: Contribution to journal › Article › peer-review

249 Scopus citations

Abstract

Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. The yeast two-hybrid system was used to screen a human complementary DNA (cDNA) library for proteins that associate with YY1, and a c-myc cDNA was isolated. Affinity chromatography confirmed that YY1 associates with c-Myc but not with Max. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1.

Original language	English (US)
Pages (from-to)	1889-1892
Number of pages	4
Journal	Science
Volume	262
Issue number	5141
DOIs	https://doi.org/10.1126/science.8266081
State	Published - 1993
Externally published	Yes

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title = "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-myc",

abstract = "Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. The yeast two-hybrid system was used to screen a human complementary DNA (cDNA) library for proteins that associate with YY1, and a c-myc cDNA was isolated. Affinity chromatography confirmed that YY1 associates with c-Myc but not with Max. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1.",

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year = "1993",

doi = "10.1126/science.8266081",

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AU - Shrivastava, A.

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AU - Artandi, S.

AU - Goff, S. P.

AU - Calame, K.

PY - 1993

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AB - Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. The yeast two-hybrid system was used to screen a human complementary DNA (cDNA) library for proteins that associate with YY1, and a c-myc cDNA was isolated. Affinity chromatography confirmed that YY1 associates with c-Myc but not with Max. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1.

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Inhibition of transcriptional regulator Yin-Yang-1 by association with c-myc

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