Infantile status epilepticus and future seizure susceptibility in the rat

Reiko Okada, Solomon L. Moshé, Bruce J. Albala

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


The long-term effects of infantile seizures on the development of seizures in adulthood were studied in rats. Infantile seizures of varying severity were induced with intraperitoneal injections of kainic acid in 15-day-old rats. In adulthood the seizure susceptibility of the rats was determined by kindling the left amygdala and by measuring their ability to resist recurrent seizures. The results suggest that infantile status epilepticus is associated with a very high mortality; however in the surviving rats, infantile seizures even as severe as status epilepticus do not cause neuronal brain damage and do not predispose to the development of convulsions later in life.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalDevelopmental Brain Research
Issue number2
StatePublished - Aug 1984


  • animal newborn
  • epilepsy
  • hippocampal sclerosis
  • kainic acid
  • kindling
  • rats
  • seizures
  • status epilepticus

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology


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