Induction of depersonalization by the serotonin agonist meta-chlorophenylpiperazine

Daphne Simeon, Eric Hollander, Dan J. Stein, Concetta DeCaria, Lisa J. Cohen, Jihad B. Saoud, Nazrul Islam, Michael Hwang

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Sixty-seven subjects, including normal volunteers and patients with obsessive-compulsive disorder, social phobia, and borderline personality disorder, received ratings of depersonalization after double-blind, placebo-controlled challenges with the partial serotonin agonist meta-chlorophenylpiperazine (m-CPP). Challenge with m-CPP induced depersonalization significantly more than did placebo. Subjects who became depersonalized did not differ in age, sex, or diagnosis from those who did not experience depersonalization. There was a significant correlation between the induction of depersonalization and increase in panic, but not nervousness, anxiety, sadness, depression, or drowsiness. This report suggests that serotonergic dysregulation may in part underlie depersonalization.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalPsychiatry Research
Issue number2
StatePublished - Sep 29 1995
Externally publishedYes


  • Borderline personality disorder
  • Obsessive-compulsive disorder
  • Panic
  • Social phobia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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