Abstract
A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non-self protein human cytochrome c can present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form. This mechanism of breaking T cell self tolerance could account for the role of foreign antigens in breaking not only B cell but also T cell self tolerance, leading to sustained autoantibody production in the absence of the foreign antigen.
Original language | English (US) |
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Pages (from-to) | 1433-1439 |
Number of pages | 7 |
Journal | Journal of Experimental Medicine |
Volume | 173 |
Issue number | 6 |
State | Published - Jun 1 1991 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology