Increasing the efficacy of bioorthogonal click reactions for bioconjugation: A comparative study

Christen Besanceney-Webler; Hao Jiang; Tianqing Zheng; Lei Feng; David Soriano Del Amo; Wei Wang; Liana M. Klivansky; Florence L. Marlow; Yi Liu; Peng Wu

doi:10.1002/anie.201101817

Increasing the efficacy of bioorthogonal click reactions for bioconjugation: A comparative study

Christen Besanceney-Webler, Hao Jiang, Tianqing Zheng, Lei Feng, David Soriano Del Amo, Wei Wang, Liana M. Klivansky, Florence L. Marlow, Yi Liu, Peng Wu

Research output: Contribution to journal › Article › peer-review

318 Scopus citations

Abstract

Raising the bar: The efficacy of bioorthogonal reactions for bioconjugation has been thoroughly evaluated in four different biological settings. Powered by the development of new biocompatible ligands, the copper-catalyzed azide-alkyne cycloaddition (see picture) has brought about unsurpassed bioconjugation efficiency, and thus it holds great promise as a highly potent and adaptive tool for a broader spectrum of biological applications.

Original language	English (US)
Pages (from-to)	8051-8056
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	35
DOIs	https://doi.org/10.1002/anie.201101817
State	Published - Aug 22 2011
Externally published	Yes

Keywords

alkynes
azides
bioconjugation
bioorthogonal reactions
click chemistry

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201101817

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abstract = "Raising the bar: The efficacy of bioorthogonal reactions for bioconjugation has been thoroughly evaluated in four different biological settings. Powered by the development of new biocompatible ligands, the copper-catalyzed azide-alkyne cycloaddition (see picture) has brought about unsurpassed bioconjugation efficiency, and thus it holds great promise as a highly potent and adaptive tool for a broader spectrum of biological applications.",

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AU - Besanceney-Webler, Christen

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AU - Zheng, Tianqing

AU - Feng, Lei

AU - Soriano Del Amo, David

AU - Wang, Wei

AU - Klivansky, Liana M.

AU - Marlow, Florence L.

AU - Liu, Yi

AU - Wu, Peng

PY - 2011/8/22

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AB - Raising the bar: The efficacy of bioorthogonal reactions for bioconjugation has been thoroughly evaluated in four different biological settings. Powered by the development of new biocompatible ligands, the copper-catalyzed azide-alkyne cycloaddition (see picture) has brought about unsurpassed bioconjugation efficiency, and thus it holds great promise as a highly potent and adaptive tool for a broader spectrum of biological applications.

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KW - azides

KW - bioconjugation

KW - bioorthogonal reactions

KW - click chemistry

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Increasing the efficacy of bioorthogonal click reactions for bioconjugation: A comparative study

Abstract

Keywords

ASJC Scopus subject areas

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