Increased iron content in the putamen of patients with striatonigral degeneration

S. Kato; S. Meshitsuka; E. Ohama; J. Tanaka; J. F. Llena; A. Hirano

doi:10.1007/BF00227827

Increased iron content in the putamen of patients with striatonigral degeneration

S. Kato, S. Meshitsuka, E. Ohama, J. Tanaka, J. F. Llena, A. Hirano

Pathology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We measured the total content of iron, cooper, zinc and manganese in the putamen of four patients with striatonigral degeneration (SND) and age-and gender-matched normal controls. The iron content in the SND patients was five times greater than in the controls. Electron microscopic histochemistry revealed the iron reaction products in the pigments showing a triphasic pattern of coarse, electron-dense globules, fine granular and fibrillary materials, and lamellated structures. These findings suggest that increased iron deposition may be related to pigment formation in the putament of SND.

Original language	English (US)
Pages (from-to)	328-330
Number of pages	3
Journal	Acta neuropathologica
Volume	84
Issue number	3
DOIs	https://doi.org/10.1007/BF00227827
State	Published - Aug 1 1992

Keywords

Atomic absorption spectroscopy
Electron microscopy
Iron
Putaminal pigment
Striatonigral degeneration

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1007/BF00227827

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title = "Increased iron content in the putamen of patients with striatonigral degeneration",

abstract = "We measured the total content of iron, cooper, zinc and manganese in the putamen of four patients with striatonigral degeneration (SND) and age-and gender-matched normal controls. The iron content in the SND patients was five times greater than in the controls. Electron microscopic histochemistry revealed the iron reaction products in the pigments showing a triphasic pattern of coarse, electron-dense globules, fine granular and fibrillary materials, and lamellated structures. These findings suggest that increased iron deposition may be related to pigment formation in the putament of SND.",

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AU - Kato, S.

AU - Meshitsuka, S.

AU - Ohama, E.

AU - Tanaka, J.

AU - Llena, J. F.

AU - Hirano, A.

PY - 1992/8/1

Y1 - 1992/8/1

N2 - We measured the total content of iron, cooper, zinc and manganese in the putamen of four patients with striatonigral degeneration (SND) and age-and gender-matched normal controls. The iron content in the SND patients was five times greater than in the controls. Electron microscopic histochemistry revealed the iron reaction products in the pigments showing a triphasic pattern of coarse, electron-dense globules, fine granular and fibrillary materials, and lamellated structures. These findings suggest that increased iron deposition may be related to pigment formation in the putament of SND.

AB - We measured the total content of iron, cooper, zinc and manganese in the putamen of four patients with striatonigral degeneration (SND) and age-and gender-matched normal controls. The iron content in the SND patients was five times greater than in the controls. Electron microscopic histochemistry revealed the iron reaction products in the pigments showing a triphasic pattern of coarse, electron-dense globules, fine granular and fibrillary materials, and lamellated structures. These findings suggest that increased iron deposition may be related to pigment formation in the putament of SND.

KW - Atomic absorption spectroscopy

KW - Electron microscopy

KW - Iron

KW - Putaminal pigment

KW - Striatonigral degeneration

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Increased iron content in the putamen of patients with striatonigral degeneration

Abstract

Keywords

ASJC Scopus subject areas

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