Increased iron content in the putamen of patients with striatonigral degeneration

S. Kato, S. Meshitsuka, E. Ohama, J. Tanaka, J. F. Llena, A. Hirano

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


We measured the total content of iron, cooper, zinc and manganese in the putamen of four patients with striatonigral degeneration (SND) and age-and gender-matched normal controls. The iron content in the SND patients was five times greater than in the controls. Electron microscopic histochemistry revealed the iron reaction products in the pigments showing a triphasic pattern of coarse, electron-dense globules, fine granular and fibrillary materials, and lamellated structures. These findings suggest that increased iron deposition may be related to pigment formation in the putament of SND.

Original languageEnglish (US)
Pages (from-to)328-330
Number of pages3
JournalActa neuropathologica
Issue number3
StatePublished - Aug 1 1992


  • Atomic absorption spectroscopy
  • Electron microscopy
  • Iron
  • Putaminal pigment
  • Striatonigral degeneration

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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