Abstract
Sex-based differences in CD4 T-cell (CD4) counts are well recognized, but the basis for these differences has not been identified. Conceivably, homeostatic factors may play a role in this process by regulating T-cell maintenance and repletion. Interleukin (IL)-7 is essential for normal T-cell production and homeostasis. We hypothesized that differences in IL-7 might contribute to sex-based differences in CD4 counts. Circulating IL-7 levels were analyzed in 299 HIV-1-infected women and men. Regression analysis estimated that IL-7 levels were 40% higher in women than in men (P = 0.0032) after controlling for CD4 count, age, and race. Given the important role of IL-7 in T-cell development and homeostasis, these findings suggest that higher IL-7 levels may contribute to higher CD4 counts in women.
Original language | English (US) |
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Pages (from-to) | 581-584 |
Number of pages | 4 |
Journal | Journal of Acquired Immune Deficiency Syndromes |
Volume | 40 |
Issue number | 5 |
DOIs | |
State | Published - Dec 2005 |
Keywords
- CD4-positive T cells
- Cytokines
- Interleukin-7
- Sex differences
- Sexual dimorphism
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)