TY - JOUR
T1 - Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis
AU - Freitas, Dayvison F.S.
AU - Santos, Suelen S.
AU - Almeida-Paes, Rodrigo
AU - De Oliveira, Manoel M.E.
AU - Do Valle, Antonio C.F.
AU - Gutierrez-Galhardo, Maria Clara
AU - Zancopé-Oliveira, Rosely M.
AU - Nosanchuk, Joshua D.
N1 - Publisher Copyright:
© 2015 Taylor & Francis Group, LLC.
PY - 2015/2/10
Y1 - 2015/2/10
N2 - The metropolitan region of Rio de Janeiro is hyperendemic for cat-associated sporotrichosis. This study aimed to assess the virulence of serial Sporothrix isolates from a 61-year-old male patient with chronic, destructive disseminated sporotrichosis. Five Sporothrix isolates were cultured from skin exudates and bone samples over a 5-year period, and all were molecularly identified as Sporothrix brasiliensis. The final isolate was significantly more virulent in Galleria mellonella larvae compared to earlier isolates. We conclude that S. brasiliensis has the capacity to increase in virulence in vivo. This finding is significant to clinicians caring for individuals with S. brasiliensis disease and it suggests that further studies are needed to identify the mechanisms underlying pathogenicity enhancement during chronic disease.
AB - The metropolitan region of Rio de Janeiro is hyperendemic for cat-associated sporotrichosis. This study aimed to assess the virulence of serial Sporothrix isolates from a 61-year-old male patient with chronic, destructive disseminated sporotrichosis. Five Sporothrix isolates were cultured from skin exudates and bone samples over a 5-year period, and all were molecularly identified as Sporothrix brasiliensis. The final isolate was significantly more virulent in Galleria mellonella larvae compared to earlier isolates. We conclude that S. brasiliensis has the capacity to increase in virulence in vivo. This finding is significant to clinicians caring for individuals with S. brasiliensis disease and it suggests that further studies are needed to identify the mechanisms underlying pathogenicity enhancement during chronic disease.
KW - Brazil
KW - Chitin synthase
KW - Disseminated
KW - Galleria mellonella
KW - Reactive nitrogen intermediates
KW - Rio de Janeiro
KW - Sporothrix brasiliensis
KW - Sporotrichosis
KW - T3B PCR
KW - Virulence
UR - http://www.scopus.com/inward/record.url?scp=84926668057&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84926668057&partnerID=8YFLogxK
U2 - 10.1080/21505594.2015.1014274
DO - 10.1080/21505594.2015.1014274
M3 - Letter
C2 - 25668479
AN - SCOPUS:84926668057
SN - 2150-5594
VL - 6
SP - 112
EP - 120
JO - Virulence
JF - Virulence
IS - 2
ER -
