TY - JOUR
T1 - In vivo, noninvasive functional measurements of bone sarcoma using diffuse optical spectroscopic imaging
AU - Peterson, Hannah M.
AU - Hoang, Bang H.
AU - Geller, David
AU - Yang, Rui
AU - Gorlick, Richard
AU - Berger, Jeremy
AU - Tingling, Janet
AU - Roth, Michael
AU - Gill, Jonathon
AU - Roblyer, Darren
N1 - Funding Information:
The authors thank the patients who agreed to participate in the study. The authors gratefully acknowledge funding from the St. Baldrick’s Foundation (Research Grant Award ID: 426642). The authors also thank Bruce Tromberg, Amanda Durkin, Anais Leproux, Brian Hill, and Thomas O’Sullivan for their technical assistance during this project. This work was made possible in part by the Laser Microbeam and Medical Program (LAMMP: P41 EB015890-33), an NIH/NIBIB Biotechnology Resource Center.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Diffuse optical spectroscopic imaging (DOSI) is an emerging near-infrared imaging technique that noninvasively measures quantitative functional information in thick tissue. This study aimed to assess the feasibility of using DOSI to measure optical contrast from bone sarcomas. These tumors are rare and pose technical and practical challenges for DOSI measurements due to the varied anatomic locations and tissue depths of presentation. Six subjects were enrolled in the study. One subject was unable to be measured due to tissue contact sensitivity. For the five remaining subjects, the signal-to-noise ratio, imaging depth, optical properties, and quantitative tissue concentrations of oxyhemoglobin, deoxyhemoglobin, water, and lipids from tumor and contralateral normal tissues were assessed. Statistical differences between tumor and contralateral normal tissue were found in chromophore concentrations and optical properties for four subjects. Low signal-tonoise was encountered during several subjects measurements, suggesting increased detector sensitivity will help to optimize DOSI for this patient population going forward. This study demonstrates that DOSI is capable of measuring optical properties and obtaining functional information in bone sarcomas. In the future, DOSI may provide a means to stratify treatment groups and monitor chemotherapy response for this disease.
AB - Diffuse optical spectroscopic imaging (DOSI) is an emerging near-infrared imaging technique that noninvasively measures quantitative functional information in thick tissue. This study aimed to assess the feasibility of using DOSI to measure optical contrast from bone sarcomas. These tumors are rare and pose technical and practical challenges for DOSI measurements due to the varied anatomic locations and tissue depths of presentation. Six subjects were enrolled in the study. One subject was unable to be measured due to tissue contact sensitivity. For the five remaining subjects, the signal-to-noise ratio, imaging depth, optical properties, and quantitative tissue concentrations of oxyhemoglobin, deoxyhemoglobin, water, and lipids from tumor and contralateral normal tissues were assessed. Statistical differences between tumor and contralateral normal tissue were found in chromophore concentrations and optical properties for four subjects. Low signal-tonoise was encountered during several subjects measurements, suggesting increased detector sensitivity will help to optimize DOSI for this patient population going forward. This study demonstrates that DOSI is capable of measuring optical properties and obtaining functional information in bone sarcomas. In the future, DOSI may provide a means to stratify treatment groups and monitor chemotherapy response for this disease.
KW - diffuse optics
KW - in vivo imaging
KW - near-infrared
KW - therapeutic monitoring
KW - tissue spectroscopy
KW - translational research
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U2 - 10.1117/1.JBO.22.12.121612
DO - 10.1117/1.JBO.22.12.121612
M3 - Article
C2 - 29264893
AN - SCOPUS:85042410796
SN - 1083-3668
VL - 22
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 12
M1 - 121612
ER -