In vivo MR imaging and spectroscopy using hyperpolarized 129Xe

Mark E. Wagshul, Terry M. Button, Haifang F. Li, Zhengrong Liang, Charles S. Springer, Kai Zhong, Arnold Wishnia

Research output: Contribution to journalArticlepeer-review

136 Scopus citations


Hyperpolarized 129Xe has been used to obtain gas phase images of mouse lung in vivo, showing distinct ventilation variation as a function of the breathing cycle. Spectra of 129Xe in the thorax show complex structure in both the gas phase (-4 to 3 ppm) and tissue-dissolved (190-205 ppm) regions. The alveolar gas peak shows correlated intensity and frequency oscillations, both attributable to changes in lung volume during breathing. The two major dissolved peaks near 198-200 ppm are attributed to lung parenchyma and to blood; they reach maximum intensity in 5-10 s and decay with an apparent T1 of 30 s. Another peak at 190 ppm takes 20-30 s to reach maximum; this must represent other well-vascularized tissue (e.g., heart and other muscles) in the thorax. The maximum integrated area of the tissue components reaches 30-80% of the maximum alveolar gas area, indicating that imaging at tissue frequencies can be achieved.

Original languageEnglish (US)
Pages (from-to)183-191
Number of pages9
JournalMagnetic Resonance in Medicine
Issue number2
StatePublished - Aug 1996
Externally publishedYes


  • MRI of lung
  • bulk magnetic susceptibility
  • hyperpolarized Xe
  • in vivo Xe spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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