Improvement of left ventricular mass with antihypertensive therapy in children with hypertension

Juan C. Kupferman, Kara Paterno, Joseph Mahgerefteh, Murali Pagala, Meg Golden, Irene D. Lytrivi, Prema Ramaswamy

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


There is paucity of data on the regression of left ventricular hypertrophy (LVH) in hypertensive children. This study assessed the effects of antihypertensive therapy on left ventricular mass in children with and without LVH. Medical records of hypertensive patients who had a baseline and follow-up echocardiogram (echo 1, echo 2) were reviewed. Fifteen of 22 treated patients had LVH at echo 1. Enalapril alone or combined was used in 21/22 cases. Echo 2 was performed at a mean interval of 15±7 months. The LVH group showed significant decrease in systolic blood pressure z-score (SBPZ) (2.89±1.61 to 1.40±1.19; p=0.01), diastolic blood pressure z-score (DBPZ) (1.44±0.90 to 0.26±0.82; p<0.001), and LV mass index (LVMI) (56.2±12.50 to 43.7±8.30; p=0.001), but no significant change in body mass index z-score (BMIZ) (1.79±0.75 to 1.69±0.69; p=0.74). In the no-LVH group, SBPZ (3.03±1.68 to 2.27±1.81; p=0.356), DBPZ (1.00±0.87 to 0.63±0.68; p=0.409), BMIZ (1.08±0.98 to 1.27±0.89; p=0.672), and LVMI (29.47±5.51 to 33.89±3.06; p=0.374) did not change significantly. Simple linear regression demonstrated that the change in LVMI in the combined group had a significant correlation (r=0.477; p=0.025) with the percentage change in SBPZ. This study demonstrates that LVH in hypertensive children improves with effective blood pressure control.

Original languageEnglish (US)
Pages (from-to)1513-1518
Number of pages6
JournalPediatric Nephrology
Issue number8
StatePublished - Aug 2010


  • Blood pressure
  • Childhood
  • End-organ damage
  • Heart
  • Left ventricular hypertrophy
  • Regression
  • Treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology


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