Abstract
The fibrinolytic activity present in the euglobulin (EU) fraction of BALB c mice before and during the growth of M3 and MM3 murine mammary adenocarcinomas was characterized. The main plasminogen activator (PA) form contained in EUs from control mice was defined as murine urokinase-type PA (uPA). Overall fibrinolytic activity decreased significantly during tumor development. Zymographies showed that this fall was associated with a reduction in the free uPA band (47 kDa) and to the detection of a tissue-type PA (tPA) complexed band (117 kDa). Western blotting showed free tPA protein (68 kDa) in control mice, that disappeared in M3 tumor-bearing mice. In this model, high subcutaneous tumor burden induces a severe impairment in the circulating fibrinolytic system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 181-187 |
| Number of pages | 7 |
| Journal | Cancer Letters |
| Volume | 70 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 16 1993 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- cancer
- euglobulins
- fibrinolysis
- mammary tumors
- mice
- plasminogen activators
ASJC Scopus subject areas
- Oncology
- Cancer Research
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