Immunohistochemical Study of the Hippocampus in Parkinsonism-Dementia Complex on Guam

Hidefumi Ito, Asao Hirano, Satoshi Goto, Shu Hui C. Yen

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


This investigation concerns the expression of paired helical filaments, tau protein, ubiquitin, β-amyloid protein, and syn aptophysin in the hippocampus of patients with parkinsonism-dementia complex on Guam (PDC) and Alzheimer's dis ease. Alzheimer's neurofibrillary tangles (NFTs) were identified in all cases of PDC and Alzheimer's disease by the modified Bielschowsky method, with which they were readily detected, and by immunohistochemical procedures using antibodies to paired helical filaments, tau protein, and ubiquitin. Observations regarding the different morphological stages indicated that NFTs were similar in PDC and Alzheimer's disease. The same markers were also useful for detecting neuropil threads, abundant in the CA1 field and the subiculum in both diseases. In the CA4 region of some PDC cases, prominent threads were noted. No senile plaques or amyloid angiopathies were seen in the hippocampus of the PDC cases examined. There was a significant decrease in synaptophysin immunoreactivity, most pronounced in the subfield CA1 and the subiculum, as well as in the outer molecular layer of the dentate gyrus, in both disorders. (J Geriatr Psychiatry Neurol 1991;4:134-142).

Original languageEnglish (US)
Pages (from-to)134-142
Number of pages9
JournalJournal of Geriatric Psychiatry and Neurology
Issue number3
StatePublished - Jul 1991

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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