Immunoglobulin expression and its biological significance in cancer cells

Duosha Hu, Hui Zheng, Haidan Liu, Ming Li, Wei Ren, Wei Liao, Zhi Duan, Lili Li, Ya Cao

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


It is generally believed that the expression of a gene is restricted "within the right place and at the right time". This principle has long been considered applicable as well to the expression of immunoglobulin (Ig) lymphocytes of B cell lineage. However, increasing evidence has shown Ig "paradoxically" expressed in malignant tumors of epithelial origin. We reviewed the recent progress in the study of cancer-derived Ig, and also discussed its mechanisms and possible functions, trying to arouse interest and attention to those working in the field of immunology and oncology.

Original languageEnglish (US)
Pages (from-to)319-324
Number of pages6
JournalCellular and Molecular Immunology
Issue number5
StatePublished - Oct 2008
Externally publishedYes


  • carcinoma
  • class switch
  • immunoglobulin
  • recombination
  • signal transduction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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