@article{15e63b78be01422ca8f71cb69ab4359e,
title = "Immunoglobulin expression and its biological significance in cancer cells",
abstract = "It is generally believed that the expression of a gene is restricted {"}within the right place and at the right time{"}. This principle has long been considered applicable as well to the expression of immunoglobulin (Ig) lymphocytes of B cell lineage. However, increasing evidence has shown Ig {"}paradoxically{"} expressed in malignant tumors of epithelial origin. We reviewed the recent progress in the study of cancer-derived Ig, and also discussed its mechanisms and possible functions, trying to arouse interest and attention to those working in the field of immunology and oncology.",
keywords = "carcinoma, class switch, immunoglobulin, recombination, signal transduction",
author = "Duosha Hu and Hui Zheng and Haidan Liu and Ming Li and Wei Ren and Wei Liao and Zhi Duan and Lili Li and Ya Cao",
note = "Funding Information: This work is supported by grants from China Medicine Board (No. 96655, No. 04-799), State Key Basic Research and Development Plan (973) of the Ministry of Science and Technology of China (No. 2004CB518703), National High Technology Research and Development Program (863) of China (No. 2006AA02A404), Key Project of National Natural Science Foundation of China (No. 38930410, No. 30530710), National Natural Science Foundation of China (No. 39080015, No. 39400153, No. 39470299, No. 39600082, No. 69700170, No. 30171047, No. 30271218, No. 30471968, No. 30570700, No. 30772465), National Natural Science Funds for Distinguished Young Scholar (No. 39525022) and Key Project of Hunan Province (04SK1001).",
year = "2008",
month = oct,
doi = "10.1038/cmi.2008.39",
language = "English (US)",
volume = "5",
pages = "319--324",
journal = "Cellular and Molecular Immunology",
issn = "1672-7681",
publisher = "Nature Publishing Group",
number = "5",
}
