“Hypothalamic Microinflammation” Paradigm in Aging and Metabolic Diseases

Dongsheng Cai; Sinan Khor

doi:10.1016/j.cmet.2019.05.021

“Hypothalamic Microinflammation” Paradigm in Aging and Metabolic Diseases

Dongsheng Cai, Sinan Khor

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

86 Scopus citations

Abstract

The hypothalamus of the brain can become inflamed during aging and in metabolic diseases. In this Perspective, Cai and Khor provide an overview of the mediators, signaling components, and physiological impact of hypothalamic microinflammation. They draw parallels between aging and the metabolic syndrome and highlight important questions to be addressed.

Original language	English (US)
Pages (from-to)	19-35
Number of pages	17
Journal	Cell metabolism
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2019.05.021
State	Published - Jul 2 2019

Keywords

NF-kB
aging
brain
diabetes
hypertension
hypothalamus
inflammation
nuclear factor kappa B
obesity

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cmet.2019.05.021

Cite this

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title = "“Hypothalamic Microinflammation” Paradigm in Aging and Metabolic Diseases",

abstract = "The hypothalamus of the brain can become inflamed during aging and in metabolic diseases. In this Perspective, Cai and Khor provide an overview of the mediators, signaling components, and physiological impact of hypothalamic microinflammation. They draw parallels between aging and the metabolic syndrome and highlight important questions to be addressed.",

keywords = "NF-kB, aging, brain, diabetes, hypertension, hypothalamus, inflammation, nuclear factor kappa B, obesity",

author = "Dongsheng Cai and Sinan Khor",

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AU - Khor, Sinan

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AB - The hypothalamus of the brain can become inflamed during aging and in metabolic diseases. In this Perspective, Cai and Khor provide an overview of the mediators, signaling components, and physiological impact of hypothalamic microinflammation. They draw parallels between aging and the metabolic syndrome and highlight important questions to be addressed.

KW - NF-kB

KW - aging

KW - brain

KW - diabetes

KW - hypertension

KW - hypothalamus

KW - inflammation

KW - nuclear factor kappa B

KW - obesity

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“Hypothalamic Microinflammation” Paradigm in Aging and Metabolic Diseases

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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