“Hypothalamic Microinflammation” Paradigm in Aging and Metabolic Diseases

Dongsheng Cai, Sinan Khor

Research output: Contribution to journalReview articlepeer-review

84 Scopus citations


The hypothalamus of the brain can become inflamed during aging and in metabolic diseases. In this Perspective, Cai and Khor provide an overview of the mediators, signaling components, and physiological impact of hypothalamic microinflammation. They draw parallels between aging and the metabolic syndrome and highlight important questions to be addressed.

Original languageEnglish (US)
Pages (from-to)19-35
Number of pages17
JournalCell metabolism
Issue number1
StatePublished - Jul 2 2019


  • NF-kB
  • aging
  • brain
  • diabetes
  • hypertension
  • hypothalamus
  • inflammation
  • nuclear factor kappa B
  • obesity

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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