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Hypoglycemic effect of combined ghrelin and glucagon receptor blockade
Bharath K. Mani
, Aki Uchida
, Young Lee
, Sherri Osborne-Lawrence
,
Maureen J. Charron
, Roger H. Unger
, Eric D. Berglund
, Jeffrey M. Zigman
Biochemistry
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peer-review
32
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Keyphrases
Blood Glucose
100%
Db Mice
25%
Diabetes
25%
Ghrelin
100%
Ghrelin Level
100%
Ghrelin Receptor
100%
Ghrelin Receptor Antagonist
25%
Glucagon
75%
Glucagon Receptor
100%
Glucagon Receptor Knockout
25%
Glycemia
25%
Hyperglycemia
75%
Hypoglycemia
50%
Hypoglycemic Activity
100%
Insulin
50%
Knock-in Mouse Model
75%
Level Rise
25%
Low Blood Glucose
25%
Monoclonal Antibody
50%
Monotherapy
25%
Null Mice
25%
Pancreatic β
25%
Plasma Ghrelin
100%
Receptor Blockade
100%
Streptozotocin
50%
Streptozotocin-induced
25%
Type 1 Diabetes Mellitus (T1DM)
50%
Type I Diabetes
50%
Pharmacology, Toxicology and Pharmaceutical Science
Antidiabetic Activity
100%
Antidiabetic Agent
12%
Controlled Release
12%
Cytotoxin
12%
Db/Db Mouse
12%
Ghrelin
100%
Ghrelin Receptor
100%
Glucagon
37%
Glucagon Receptor
100%
Glucose
62%
Hyperglycemia
37%
Hypoglycemia
25%
Insulin
25%
Insulin Dependent Diabetes Mellitus
25%
Knockout Mouse
50%
Monoclonal Antibody
25%
Monotherapy
12%
Receptor Antagonist
12%
Streptozotocin
37%
Neuroscience
Blood Plasma
50%
Ghrelin
100%
Glucagon
37%
Glucagon Receptor
100%
Glucose
62%
Growth Hormone Secretagogue Receptor
100%
Hyperglycemia
37%
Hypoglycemia
25%
Insulin
25%
Monoclonal Antibody
25%
Receptor Antagonist
12%
Streptozotocin
37%