Abstract
Transcriptionally active human papillomavirus type 6a (HPV-6a) DNA was detected in a lung carcinoma of a patient with recurrent laryngeal papillomatosis. The carcinoma contained episomal HPV-6a genomes that had a duplication of the upstream regulatory region, the late region and a portion of the early region. HPV-6a genomes found in benign laryngeal papillomas from the same patient did not contain this duplication. A role for the mutant molecules in the pathogenesis of the malignancy is suggested.
Original language | English (US) |
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Pages (from-to) | 423-428 |
Number of pages | 6 |
Journal | Journal of General Virology |
Volume | 73 |
Issue number | 2 |
DOIs | |
State | Published - 1992 |
ASJC Scopus subject areas
- Virology