Human fear-related motor neurocircuitry

T. Butler; H. Pan; O. Tuescher; A. Engelien; M. Goldstein; J. Epstein; D. Weisholtz; J. C. Root; X. Protopopescu; A. C. Cunningham-Bussel; L. Chang; X. H. Xie; Q. Chen; E. A. Phelps; J. E. Ledoux; E. Stern; D. A. Silbersweig

doi:10.1016/j.neuroscience.2007.09.048

Human fear-related motor neurocircuitry

T. Butler, H. Pan, O. Tuescher, A. Engelien, M. Goldstein, J. Epstein, D. Weisholtz, J. C. Root, X. Protopopescu, A. C. Cunningham-Bussel, L. Chang, X. H. Xie, Q. Chen, E. A. Phelps, J. E. Ledoux, E. Stern, D. A. Silbersweig

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Using functional magnetic resonance imaging and an experimental paradigm of instructed fear, we observed a striking pattern of decreased activity in primary motor cortex with increased activity in dorsal basal ganglia during anticipation of aversive electrodermal stimulation in 42 healthy participants. We interpret this pattern of activity in motor neurocircuitry in response to cognitively-induced fear in relation to evolutionarily-conserved responses to threat that may be relevant to understanding normal and pathological fear in humans.

Original language	English (US)
Pages (from-to)	1-7
Number of pages	7
Journal	Neuroscience
Volume	150
Issue number	1
DOIs	https://doi.org/10.1016/j.neuroscience.2007.09.048
State	Published - Nov 30 2007
Externally published	Yes

Keywords

amygdala
anxiety
basal ganglia
fMRI
freezing
motor cortex

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuroscience.2007.09.048

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Butler, T., Pan, H., Tuescher, O., Engelien, A., Goldstein, M., Epstein, J., Weisholtz, D., Root, J. C., Protopopescu, X., Cunningham-Bussel, A. C., Chang, L., Xie, X. H., Chen, Q., Phelps, E. A., Ledoux, J. E., Stern, E., & Silbersweig, D. A. (2007). Human fear-related motor neurocircuitry. Neuroscience, 150(1), 1-7. https://doi.org/10.1016/j.neuroscience.2007.09.048

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title = "Human fear-related motor neurocircuitry",

abstract = "Using functional magnetic resonance imaging and an experimental paradigm of instructed fear, we observed a striking pattern of decreased activity in primary motor cortex with increased activity in dorsal basal ganglia during anticipation of aversive electrodermal stimulation in 42 healthy participants. We interpret this pattern of activity in motor neurocircuitry in response to cognitively-induced fear in relation to evolutionarily-conserved responses to threat that may be relevant to understanding normal and pathological fear in humans.",

keywords = "amygdala, anxiety, basal ganglia, fMRI, freezing, motor cortex",

author = "T. Butler and H. Pan and O. Tuescher and A. Engelien and M. Goldstein and J. Epstein and D. Weisholtz and Root, {J. C.} and X. Protopopescu and Cunningham-Bussel, {A. C.} and L. Chang and Xie, {X. H.} and Q. Chen and Phelps, {E. A.} and Ledoux, {J. E.} and E. Stern and Silbersweig, {D. A.}",

note = "Funding Information: This research was supported by NIH grants P50MH058911 and 5R01MH061825. We are grateful to Jude Allen, Josefino Borja, and Wolfgang Engelien for their help with this project.",

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doi = "10.1016/j.neuroscience.2007.09.048",

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T1 - Human fear-related motor neurocircuitry

AU - Butler, T.

AU - Pan, H.

AU - Tuescher, O.

AU - Engelien, A.

AU - Goldstein, M.

AU - Epstein, J.

AU - Weisholtz, D.

AU - Root, J. C.

AU - Protopopescu, X.

AU - Cunningham-Bussel, A. C.

AU - Chang, L.

AU - Xie, X. H.

AU - Chen, Q.

AU - Phelps, E. A.

AU - Ledoux, J. E.

AU - Stern, E.

AU - Silbersweig, D. A.

N1 - Funding Information: This research was supported by NIH grants P50MH058911 and 5R01MH061825. We are grateful to Jude Allen, Josefino Borja, and Wolfgang Engelien for their help with this project.

PY - 2007/11/30

Y1 - 2007/11/30

N2 - Using functional magnetic resonance imaging and an experimental paradigm of instructed fear, we observed a striking pattern of decreased activity in primary motor cortex with increased activity in dorsal basal ganglia during anticipation of aversive electrodermal stimulation in 42 healthy participants. We interpret this pattern of activity in motor neurocircuitry in response to cognitively-induced fear in relation to evolutionarily-conserved responses to threat that may be relevant to understanding normal and pathological fear in humans.

AB - Using functional magnetic resonance imaging and an experimental paradigm of instructed fear, we observed a striking pattern of decreased activity in primary motor cortex with increased activity in dorsal basal ganglia during anticipation of aversive electrodermal stimulation in 42 healthy participants. We interpret this pattern of activity in motor neurocircuitry in response to cognitively-induced fear in relation to evolutionarily-conserved responses to threat that may be relevant to understanding normal and pathological fear in humans.

KW - amygdala

KW - anxiety

KW - basal ganglia

KW - fMRI

KW - freezing

KW - motor cortex

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VL - 150

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Human fear-related motor neurocircuitry

Abstract

Keywords

ASJC Scopus subject areas

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