TY - JOUR
T1 - Host defenses in experimental scrub typhus
T2 - Mapping the gene that controls natural resistance in mice
AU - Groves, M. G.
AU - Rosenstreich, D. L.
AU - Taylor, B. A.
AU - Osterman, J. V.
PY - 1980
Y1 - 1980
N2 - Natural resistance of mice to lethal infections of Rickettsia tsutsugamushi, strain Gilliam, is controlled by a single, autosomal, dominant gene, which we have designated Ric, with r and s representing the resistant and susceptible alleles, respectively. Using three sets of recombinant inbred mouse strains (BXD, BXH, and BXJ), the Ric locus was mapped to Chromosome 5 closely linked to the retinal degeneration (rd) locus. This linkage was confirmed by a backcross analysis. Based on the RI strains and the C57BL/6Ty-le congenic strain (the only proven Ric-rd cross-over), we estimate the recombination frequency between Ric and rd to be 0.015. Three presumptive Ric-rd recombinants detected among 93 backcross mice may represent cases of incomplete penetrance of the resistance allele rather than recombination. Analysis of the C57BL/6JTy-le congenic strain indicates that Ric is proximal to rd on Chromosome 5. If so, the correct gene order is Pgm-1-W-Ric-rd-Gus.
AB - Natural resistance of mice to lethal infections of Rickettsia tsutsugamushi, strain Gilliam, is controlled by a single, autosomal, dominant gene, which we have designated Ric, with r and s representing the resistant and susceptible alleles, respectively. Using three sets of recombinant inbred mouse strains (BXD, BXH, and BXJ), the Ric locus was mapped to Chromosome 5 closely linked to the retinal degeneration (rd) locus. This linkage was confirmed by a backcross analysis. Based on the RI strains and the C57BL/6Ty-le congenic strain (the only proven Ric-rd cross-over), we estimate the recombination frequency between Ric and rd to be 0.015. Three presumptive Ric-rd recombinants detected among 93 backcross mice may represent cases of incomplete penetrance of the resistance allele rather than recombination. Analysis of the C57BL/6JTy-le congenic strain indicates that Ric is proximal to rd on Chromosome 5. If so, the correct gene order is Pgm-1-W-Ric-rd-Gus.
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M3 - Article
C2 - 6774020
AN - SCOPUS:0018937279
SN - 0022-1767
VL - 125
SP - 1395
EP - 1399
JO - Journal of Immunology
JF - Journal of Immunology
IS - 3
ER -