TY - JOUR
T1 - HIV modifies the effect of tobacco smoking on oral human papillomavirus infection
AU - Alli, Babatunde Y.
AU - Burk, Robert D.
AU - Fatahzadeh, Mahnaz
AU - Kazimiroff, Julie
AU - Grossberg, Robert M.
AU - Smith, Richard V.
AU - Ow, Thomas J.
AU - Wiltz, Mauricio
AU - Polanco, Jacqueline
AU - Rousseau, Marie Claude
AU - Nicolau, Belinda
AU - Schlecht, Nicolas F.
N1 - Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Background. People living with HIV (PLWH) are more likely to smoke and harbor oral human papillomavirus (HPV) infections, putting them at higher risk for head and neck cancer. We investigated effects of HIV and smoking on oral HPV risk. Methods. Consecutive PLWH (n = 169) and at-risk HIV-negative individuals (n = 126) were recruited from 2 US health centers. Smoking history was collected using questionnaires. Participants provided oral rinse samples for HPV genotyping. We used multivariable logistic regression models with interaction terms for HIV to test for smoking effect on oral HPV. Results. PLWH were more likely to harbor oral HPV than HIV-negative individuals, including α (39% vs 28%), β (73% vs 63%), and γ-types (33% vs 20%). HIV infection positively modified the association between smoking and high-risk oral HPV: odds ratios for smoking 3.46 (95% confidence interval [CI], 1.01-11.94) and 1.59 (95% CI,.32-8.73) among PLWH and HIV-negative individuals, respectively, and relative excess risk due to interaction (RERI) 3.34 (95% CI, −1.51 to 8.18). RERI for HPV 16 was 1.79 (95% CI, −2.57 to 6.16) and 2.78 for β1-HPV (95% CI, −.08 to 5.65). Conclusion. Results show tobacco smoking as a risk factor for oral HPV among PLWH.
AB - Background. People living with HIV (PLWH) are more likely to smoke and harbor oral human papillomavirus (HPV) infections, putting them at higher risk for head and neck cancer. We investigated effects of HIV and smoking on oral HPV risk. Methods. Consecutive PLWH (n = 169) and at-risk HIV-negative individuals (n = 126) were recruited from 2 US health centers. Smoking history was collected using questionnaires. Participants provided oral rinse samples for HPV genotyping. We used multivariable logistic regression models with interaction terms for HIV to test for smoking effect on oral HPV. Results. PLWH were more likely to harbor oral HPV than HIV-negative individuals, including α (39% vs 28%), β (73% vs 63%), and γ-types (33% vs 20%). HIV infection positively modified the association between smoking and high-risk oral HPV: odds ratios for smoking 3.46 (95% confidence interval [CI], 1.01-11.94) and 1.59 (95% CI,.32-8.73) among PLWH and HIV-negative individuals, respectively, and relative excess risk due to interaction (RERI) 3.34 (95% CI, −1.51 to 8.18). RERI for HPV 16 was 1.79 (95% CI, −2.57 to 6.16) and 2.78 for β1-HPV (95% CI, −.08 to 5.65). Conclusion. Results show tobacco smoking as a risk factor for oral HPV among PLWH.
KW - HIV
KW - HPV
KW - Smoking
KW - Tobacco
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U2 - 10.1093/infdis/jiaa135
DO - 10.1093/infdis/jiaa135
M3 - Article
C2 - 32211783
AN - SCOPUS:85088608404
SN - 0022-1899
VL - 222
SP - 646
EP - 654
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -