Hirano bodies and related neuronal inclusions

A. Hirano

Research output: Contribution to journalReview articlepeer-review

150 Scopus citations


Hirano bodies are bright eosinophilic intracytoplasmic inclusions which have a highly characteristic crystalloid fine structure. They occur preferentially in the neuronal processes of the CA1 area in Ammon's horn in a wide variety of conditions, especially amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam, Alzheimer's disease, Pick's disease and 'normal' elderly individuals. Hirano bodies contain epitopes of actin, actin-associated proteins. tau, middle molecular weight neurofilaments subunit and a C-terminal fragment of β-amyloid precursor protein. In addition to the CA1 area of Ammon's horn, they have also been identified in many other areas of the nervous system in humans and various experimental animals. Although usually observed in neurons. Hirano bodies may also be present in other cell types. It is the consensus that Hirano bodies in the pyramidal layer of CA1 originate largely from an age-related alteration of the microfilamentous system.

Original languageEnglish (US)
Pages (from-to)3-11
Number of pages9
JournalNeuropathology and Applied Neurobiology
Issue number1
StatePublished - Jan 1 1994


  • Actin
  • Ammon's horn
  • Electron microscopy
  • Hirano bodies
  • Immunohistochemistry
  • Intraneuronal inclusions

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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