Highly functionalized organomagnesium reagents prepared through halogen-metal exchange

Paul Knochel, Wolfgang Dohle, Nina Gommermann, Florian F. Kneisel, Felix Kopp, Tobias Korn, Ioannis Sapountzis, Viet Anh Vu

Research output: Contribution to journalReview articlepeer-review

731 Scopus citations


Organomagnesium reagents occupy a central position in synthetic organic and organometallic chemistry. Recently, the halogen-magnesium exchange has considerably extended the range of functionalized Grignard reagents available for synthetic purposes. Functional groups such as esters, nitriles, iodides, imines, or even nitro groups can be present in a wide range of aromatic and heterocyclic organomagnesium reagents. Also various highly functionalized alkenyl magnesium species can be prepared. These recent developments as well as new applications of organomagnesium reagents in cross-coupling reactions and amination reactions will be covered in this Review.

Original languageEnglish (US)
Pages (from-to)4302-4320
Number of pages19
JournalAngewandte Chemie - International Edition
Issue number36
StatePublished - Sep 22 2003
Externally publishedYes


  • C-C coupling
  • Grignard reaction
  • Magnesium
  • Organometallic compounds
  • Synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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