High-resolution mapping of iso-orientation columns by fMRI

Dae Shik Kim, Timothy Q. Duong, Seong Gi Kim

Research output: Contribution to journalArticlepeer-review

344 Scopus citations


Blood-oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is an important tool for localizing brain functions in vivo. However, the ability of BOLD fMRI to map cortical columnar structures is highly controversial, as the ultimate functional specificity of BOLD remains unknown. Here we report a biphasic BOLD response to visual stimulation in the primary visual cortex of cats. In functional imaging, the initial BOLD signal decrease accurately labeled individual iso-orientation columns. In contrast, the delayed positive BOLD changes indicated the pattern of overall activation in the visual cortex, but were less suited to discriminate active from inactive columns.

Original languageEnglish (US)
Pages (from-to)164-169
Number of pages6
JournalNature Neuroscience
Issue number2
StatePublished - Feb 2000
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience


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