High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma–implications for staging

Ana Acuna-Villaorduna; Jesus Gonzalez-Lugo; B. Hilda Ye; Diego Andres Adrianzen Herrera; R. Alejandro Sica; Urvi Shah; Nishi Shah; Noah Kornblum; Ira Braunschweig; Olga Derman; Ioannis Mantzaris; Aditi Shastri; Yanhua Wang; Amit Verma; Benjamin Zalta; Murali Janakiram

doi:10.1080/10428194.2019.1627543

High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma–implications for staging

Ana Acuna-Villaorduna, Jesus Gonzalez-Lugo, B. Hilda Ye, Diego Andres Adrianzen Herrera, R. Alejandro Sica, Urvi Shah, Nishi Shah, Noah Kornblum, Ira Braunschweig, Olga Derman, Ioannis Mantzaris, Aditi Shastri, Yanhua Wang, Amit Verma, Benjamin Zalta, Murali Janakiram

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Lung involvement has been reported in HTLV-1 carriers and in patients with ATLL. Whether there are differences in the pattern of lung involvement between ATLL and HTLV carriers in North American patients is unknown. We aimed to compare CT pulmonary findings among patients with HTLV-1 infection with and without ATLL. Among 140 patients with HTLV-1 diagnosis, 97 had CT chest available. Of these, 72 (74.2%) had ATLL and 25 (25.8%) did not have ATLL. CT chest abnormalities were present in 90 (92.8%) participants (94.4% in ATLL; 88% in non-ATLL). Higher rates of lymphadenopathy (69.4% versus 24%, p <.01) and lower rates of bronchiectasis (25% versus 48%, p =.04) were seen in ATLL compared to non-ATLL. Our study supports that staging of lung involvement in ATLL should consider HTLV-associated pulmonary findings as not all CT chest abnormalities necessarily represent malignant infiltration.

Original language	English (US)
Pages (from-to)	3272-3276
Number of pages	5
Journal	Leukemia and Lymphoma
Volume	60
Issue number	13
DOIs	https://doi.org/10.1080/10428194.2019.1627543
State	Published - Nov 10 2019

Keywords

ATLL
HTLV-1
T-cell lymphoma

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10428194.2019.1627543

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Acuna-Villaorduna, A., Gonzalez-Lugo, J., Ye, B. H., Adrianzen Herrera, D. A., Sica, R. A., Shah, U., Shah, N., Kornblum, N., Braunschweig, I., Derman, O., Mantzaris, I., Shastri, A., Wang, Y., Verma, A., Zalta, B., & Janakiram, M. (2019). High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma–implications for staging. Leukemia and Lymphoma, 60(13), 3272-3276. https://doi.org/10.1080/10428194.2019.1627543

High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma–implications for staging. / Acuna-Villaorduna, Ana; Gonzalez-Lugo, Jesus; Ye, B. Hilda et al.
In: Leukemia and Lymphoma, Vol. 60, No. 13, 10.11.2019, p. 3272-3276.

Research output: Contribution to journal › Article › peer-review

Acuna-Villaorduna, A, Gonzalez-Lugo, J, Ye, BH, Adrianzen Herrera, DA, Sica, RA, Shah, U, Shah, N , Kornblum, N, Braunschweig, I, Derman, O, Mantzaris, I , Shastri, A , Wang, Y , Verma, A, Zalta, B & Janakiram, M 2019, 'High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma–implications for staging', Leukemia and Lymphoma, vol. 60, no. 13, pp. 3272-3276. https://doi.org/10.1080/10428194.2019.1627543

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abstract = "Lung involvement has been reported in HTLV-1 carriers and in patients with ATLL. Whether there are differences in the pattern of lung involvement between ATLL and HTLV carriers in North American patients is unknown. We aimed to compare CT pulmonary findings among patients with HTLV-1 infection with and without ATLL. Among 140 patients with HTLV-1 diagnosis, 97 had CT chest available. Of these, 72 (74.2%) had ATLL and 25 (25.8%) did not have ATLL. CT chest abnormalities were present in 90 (92.8%) participants (94.4% in ATLL; 88% in non-ATLL). Higher rates of lymphadenopathy (69.4% versus 24%, p <.01) and lower rates of bronchiectasis (25% versus 48%, p =.04) were seen in ATLL compared to non-ATLL. Our study supports that staging of lung involvement in ATLL should consider HTLV-associated pulmonary findings as not all CT chest abnormalities necessarily represent malignant infiltration.",

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AU - Acuna-Villaorduna, Ana

AU - Gonzalez-Lugo, Jesus

AU - Ye, B. Hilda

AU - Adrianzen Herrera, Diego Andres

AU - Sica, R. Alejandro

AU - Shah, Urvi

AU - Shah, Nishi

AU - Kornblum, Noah

AU - Braunschweig, Ira

AU - Derman, Olga

AU - Mantzaris, Ioannis

AU - Shastri, Aditi

AU - Wang, Yanhua

AU - Verma, Amit

AU - Zalta, Benjamin

AU - Janakiram, Murali

PY - 2019/11/10

Y1 - 2019/11/10

N2 - Lung involvement has been reported in HTLV-1 carriers and in patients with ATLL. Whether there are differences in the pattern of lung involvement between ATLL and HTLV carriers in North American patients is unknown. We aimed to compare CT pulmonary findings among patients with HTLV-1 infection with and without ATLL. Among 140 patients with HTLV-1 diagnosis, 97 had CT chest available. Of these, 72 (74.2%) had ATLL and 25 (25.8%) did not have ATLL. CT chest abnormalities were present in 90 (92.8%) participants (94.4% in ATLL; 88% in non-ATLL). Higher rates of lymphadenopathy (69.4% versus 24%, p <.01) and lower rates of bronchiectasis (25% versus 48%, p =.04) were seen in ATLL compared to non-ATLL. Our study supports that staging of lung involvement in ATLL should consider HTLV-associated pulmonary findings as not all CT chest abnormalities necessarily represent malignant infiltration.

AB - Lung involvement has been reported in HTLV-1 carriers and in patients with ATLL. Whether there are differences in the pattern of lung involvement between ATLL and HTLV carriers in North American patients is unknown. We aimed to compare CT pulmonary findings among patients with HTLV-1 infection with and without ATLL. Among 140 patients with HTLV-1 diagnosis, 97 had CT chest available. Of these, 72 (74.2%) had ATLL and 25 (25.8%) did not have ATLL. CT chest abnormalities were present in 90 (92.8%) participants (94.4% in ATLL; 88% in non-ATLL). Higher rates of lymphadenopathy (69.4% versus 24%, p <.01) and lower rates of bronchiectasis (25% versus 48%, p =.04) were seen in ATLL compared to non-ATLL. Our study supports that staging of lung involvement in ATLL should consider HTLV-associated pulmonary findings as not all CT chest abnormalities necessarily represent malignant infiltration.

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KW - T-cell lymphoma

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High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma–implications for staging

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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