High Elevations of Creatine Phosphokinase in Hypothyroidism: An Isoenzyme Analysis

Joel Goldman, Robert Matz, Robin Mortimer, Ruth Freeman

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


In hypothyroidism, slight elevations of serum creatine phosphokinase (CPK) levels are common. In contrast, we describe six hypothyroid patients with extreme elevations (17- to 160-fold) of CPK levels. Enzyme analysis showed only MM isoenzyme in four cases and MM plus trace MB isoenzyme in two patients. Hypothyroidism should, therefore, be considered when elevated CPK levels, even if extreme, are found. Isoenzyme analysis in such a case will show primarily an MM pattern, although trace MB fraction can also be seen. This isoenzyme pattern suggests that the source of the CPK elevations is skeletal muscle.

Original languageEnglish (US)
Pages (from-to)325-326
Number of pages2
JournalJAMA: The Journal of the American Medical Association
Issue number4
StatePublished - Jul 25 1977

ASJC Scopus subject areas

  • General Medicine


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