Hepatoblastoma in a mosaic trisomy 18 patient

Elaine Maria Pereira; Robert Marion; K. H. Ramesh; Jane S. Kim; Michelle Ewart; Rosanna Ricafort

doi:10.1097/MPH.0b013e3182459ee8

Hepatoblastoma in a mosaic trisomy 18 patient

Elaine Maria Pereira, Robert Marion, K. H. Ramesh, Jane S. Kim, Michelle Ewart, Rosanna Ricafort

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We report a case of hepatoblastoma in a 10-year-old girl with mosaic-type trisomy 18. A comprehensive literature review reveals only 2 cases involving mosaic trisomy 18 patients. Our patient underwent an abbreviated chemotherapy course before complete surgical resection. Her hepatoblastoma did not contain cells with trisomy 18. The conservative management approach resulted in a successful outcome; she remains disease free >2 years after surgery. Along with presenting a literature review, this report demonstrates a favorable outcome in a mosaic trisomy 18 child with hepatoblastoma where tumor cells lacked a trisomy 18 karyotype.

Original language	English (US)
Pages (from-to)	e145-e148
Journal	Journal of Pediatric Hematology/Oncology
Volume	34
Issue number	4
DOIs	https://doi.org/10.1097/MPH.0b013e3182459ee8
State	Published - May 2012

Keywords

Cytogenetics
Mosaic
Trisomy 18
hepatoblastoma

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1097/MPH.0b013e3182459ee8

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title = "Hepatoblastoma in a mosaic trisomy 18 patient",

abstract = "We report a case of hepatoblastoma in a 10-year-old girl with mosaic-type trisomy 18. A comprehensive literature review reveals only 2 cases involving mosaic trisomy 18 patients. Our patient underwent an abbreviated chemotherapy course before complete surgical resection. Her hepatoblastoma did not contain cells with trisomy 18. The conservative management approach resulted in a successful outcome; she remains disease free >2 years after surgery. Along with presenting a literature review, this report demonstrates a favorable outcome in a mosaic trisomy 18 child with hepatoblastoma where tumor cells lacked a trisomy 18 karyotype.",

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AU - Marion, Robert

AU - Ramesh, K. H.

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AU - Ewart, Michelle

AU - Ricafort, Rosanna

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AB - We report a case of hepatoblastoma in a 10-year-old girl with mosaic-type trisomy 18. A comprehensive literature review reveals only 2 cases involving mosaic trisomy 18 patients. Our patient underwent an abbreviated chemotherapy course before complete surgical resection. Her hepatoblastoma did not contain cells with trisomy 18. The conservative management approach resulted in a successful outcome; she remains disease free >2 years after surgery. Along with presenting a literature review, this report demonstrates a favorable outcome in a mosaic trisomy 18 child with hepatoblastoma where tumor cells lacked a trisomy 18 karyotype.

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KW - hepatoblastoma

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Hepatoblastoma in a mosaic trisomy 18 patient

Abstract

Keywords

ASJC Scopus subject areas

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