Halogen-magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids

Felix Kopp, Stefan Wunderlich, Paul Knochel

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The magnesiation of halogenated aromatic and heteroaromatic carboxylic acids is accomplished by their treatment with MeMgCl in the presence of LiCl and subsequent reaction with i-PrMgCl·LiCl; the resulting double-magnesiated species react with a variety of electrophiles in up to 97% yield.

Original languageEnglish (US)
Pages (from-to)2075-2077
Number of pages3
JournalChemical Communications
Issue number20
DOIs
StatePublished - 2007
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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