H-Y Antigen in a 46, XX Female with Dysgenetic Ovaries

Bruce Shickmanter; Stephen Wachtel; Linda Cahill; Jeffrey Ross; Michael Shreefter; Enoch Booth; Robert E. Scully

doi:10.1210/jcem-60-5-1042

H-Y Antigen in a 46, XX Female with Dysgenetic Ovaries

Bruce Shickmanter, Stephen Wachtel, Linda Cahill, Jeffrey Ross, Michael Shreefter, Enoch Booth, Robert E. Scully

Research output: Contribution to journal › Article › peer-review

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Abstract

Hypogonadism secondary to ovarian dysgenesis or resistant ovary syndrome was diagnosed in a 19-yr-old obese woman with primary amenorrhea, a 46.XX karyotype, and an H-Y⁺ cellular phenotype. Small ovoid gonads (1.5 × 0.6 cm) were found bilaterally; these were encased in a dense venous network. The stroma was ovarian, and primordial follicles and some primary follicles were present, but there were no follicles at or beyond the antrum stage. There was no evidence of testicular tissue and no evidence of malignancy. Analysis of serological data indicated the possibility of residual H-Y antigen in the blood cells of the mother.

Original language	English (US)
Pages (from-to)	1042-1046
Number of pages	5
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	60
Issue number	5
DOIs	https://doi.org/10.1210/jcem-60-5-1042
State	Published - May 1985
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1210/jcem-60-5-1042

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title = "H-Y Antigen in a 46, XX Female with Dysgenetic Ovaries",

abstract = "Hypogonadism secondary to ovarian dysgenesis or resistant ovary syndrome was diagnosed in a 19-yr-old obese woman with primary amenorrhea, a 46.XX karyotype, and an H-Y+ cellular phenotype. Small ovoid gonads (1.5 × 0.6 cm) were found bilaterally; these were encased in a dense venous network. The stroma was ovarian, and primordial follicles and some primary follicles were present, but there were no follicles at or beyond the antrum stage. There was no evidence of testicular tissue and no evidence of malignancy. Analysis of serological data indicated the possibility of residual H-Y antigen in the blood cells of the mother.",

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T1 - H-Y Antigen in a 46, XX Female with Dysgenetic Ovaries

AU - Shickmanter, Bruce

AU - Wachtel, Stephen

AU - Cahill, Linda

AU - Ross, Jeffrey

AU - Shreefter, Michael

AU - Booth, Enoch

AU - Scully, Robert E.

PY - 1985/5

Y1 - 1985/5

N2 - Hypogonadism secondary to ovarian dysgenesis or resistant ovary syndrome was diagnosed in a 19-yr-old obese woman with primary amenorrhea, a 46.XX karyotype, and an H-Y+ cellular phenotype. Small ovoid gonads (1.5 × 0.6 cm) were found bilaterally; these were encased in a dense venous network. The stroma was ovarian, and primordial follicles and some primary follicles were present, but there were no follicles at or beyond the antrum stage. There was no evidence of testicular tissue and no evidence of malignancy. Analysis of serological data indicated the possibility of residual H-Y antigen in the blood cells of the mother.

AB - Hypogonadism secondary to ovarian dysgenesis or resistant ovary syndrome was diagnosed in a 19-yr-old obese woman with primary amenorrhea, a 46.XX karyotype, and an H-Y+ cellular phenotype. Small ovoid gonads (1.5 × 0.6 cm) were found bilaterally; these were encased in a dense venous network. The stroma was ovarian, and primordial follicles and some primary follicles were present, but there were no follicles at or beyond the antrum stage. There was no evidence of testicular tissue and no evidence of malignancy. Analysis of serological data indicated the possibility of residual H-Y antigen in the blood cells of the mother.

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H-Y Antigen in a 46, XX Female with Dysgenetic Ovaries

Abstract

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