GPR30 predicts poor survival for ovarian cancer

Harriet O. Smith, Hugo Arias-Pulido, Dennis Y. Kuo, Tamara Howard, Clifford R. Qualls, Sang Joon Lee, Claire F. Verschraegen, Helen J. Hathaway, Nancy E. Joste, Eric R. Prossnitz

Research output: Contribution to journalArticlepeer-review

187 Scopus citations


Objectives: GPR30 is a 7-transmembrane G protein-coupled estrogen receptor that functions alongside traditional estrogen receptors to regulate cellular responses to estrogen. Recent studies suggest that GPR30 expression is linked to lower survival rates in endometrial and breast cancer. This study was conducted to evaluate GPR30 expression in ovarian tumors. Methods: GPR30 expression was analyzed using immunohistochemistry and archival specimens from 45 patients with ovarian tumors of low malignant potential (LMP) and 89 patients with epithelial ovarian cancer (EOC). Expression, defined as above or below the median (intensity times the percentage of positive epithelial cells) was correlated with predictors of adverse outcome and survival. Results: GPR30 expression above the median was observed more frequently in EOC than in LMP tumors (48.3% vs. 20%, p = 0.002), and in EOC was associated with lower 5-year survival rates (44.2% vs. 82.6%, Log-rank p < 0.001). Tumor grade and FIGO stage, the other significant predictors of survival, were used to stratify cases into "high risk" and "low risk" groups. The 5-year survival rate for "low risk" EOC (all grade 1 and Stage I/II, grade 2) was 100%. In "high risk" EOC (all grade 3 and Stage III/IV, grade 2), the difference in 5-year survival by GPR 30 expression was significant (33.3% vs. 72.4%, p = 0.001). Conclusions: The novel estrogen-responsive receptor GPR30 is preferentially expressed in "high risk" EOC and is associated with lower survival rates. Further investigation of GPR30 as a potential target for therapeutic intervention in high risk EOC is warranted.

Original languageEnglish (US)
Pages (from-to)465-471
Number of pages7
JournalGynecologic Oncology
Issue number3
StatePublished - Sep 2009


  • Epithelial ovarian carcinoma
  • GPR30
  • Low malignant potential
  • Overall survival

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


Dive into the research topics of 'GPR30 predicts poor survival for ovarian cancer'. Together they form a unique fingerprint.

Cite this