Abstract
Using isoelectric focusing (IEF) in polyacrylamide gel of neuraminidase-treated serum or plasma samples and immunofixation or caseinolytic overlay after urokinase activation of gels, a common genetic polymorphism in human plasminogen has been delineated. Two alleles PLGN(A) and PLGN(B), were observed with gene frequencies in whites of .69 and .30; in Orientals of 0.96 and .03; and in blacks of .80 and .18. Several rare alleles were also found. The distribution of phenotypes fits the Hardy-Weinberg equilibrium. Inheritance is autosomal codominant and fits the expectations of Mendelian inheritance. There is fetal synthesis, but no transplacental passage of plasminogen in either direction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 681-689 |
| Number of pages | 9 |
| Journal | American Journal of Human Genetics |
| Volume | 32 |
| Issue number | 5 |
| State | Published - 1980 |
| Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)