Generating S-nitrosothiols from hemoglobin: Mechanisms, conformational dependence, and physiological relevance

Camille J. Roche; Maria B. Cassera; David Dantsker; Rhoda Elison Hirsch; Joel M. Friedman

doi:10.1074/jbc.M113.482679

Generating S-nitrosothiols from hemoglobin: Mechanisms, conformational dependence, and physiological relevance

Camille J. Roche, Maria B. Cassera, David Dantsker, Rhoda Elison Hirsch, Joel M. Friedman

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Background: The mechanism for production of N2O3 from MetHb, nitrite, and NO is controversial. Results: An Hb intermediate attributed to heme-bound N2O3 is characterized. Conclusion: Partially met-R state Hb can function as a generator of long lived forms of bioactive NO. Significance: The results provide insight into how Hb reactivity with nitrite can be harnessed physiologically and therapeutically.

Original language	English (US)
Pages (from-to)	22408-22425
Number of pages	18
Journal	Journal of Biological Chemistry
Volume	288
Issue number	31
DOIs	https://doi.org/10.1074/jbc.M113.482679
State	Published - Aug 2 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "Background: The mechanism for production of N2O3 from MetHb, nitrite, and NO is controversial. Results: An Hb intermediate attributed to heme-bound N2O3 is characterized. Conclusion: Partially met-R state Hb can function as a generator of long lived forms of bioactive NO. Significance: The results provide insight into how Hb reactivity with nitrite can be harnessed physiologically and therapeutically.",

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AU - Cassera, Maria B.

AU - Dantsker, David

AU - Hirsch, Rhoda Elison

AU - Friedman, Joel M.

PY - 2013/8/2

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Generating S-nitrosothiols from hemoglobin: Mechanisms, conformational dependence, and physiological relevance

Abstract

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