Abstract
Premenstrual dysphoric disorder (PMDD) is characterized by depression, anxiety and other affective symptoms which recur in the luteal phase of the menstrual cycle. Evidence from animal models of depression and anxiety indicate the importance of neuroactive steroid hormones and the GABAA receptor in the etiology and potential treatment of mood disorders. These data are reviewed in the light of human clinical studies and specific animal models of PMDD.
Original language | English (US) |
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Pages (from-to) | 23-41 |
Number of pages | 19 |
Journal | Archives of Women's Mental Health |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2003 |
Externally published | Yes |
Keywords
- Allopregnanolone
- Animal model
- Anxiety
- Benzodiazepine
- Depression
- GABA
- GABAR subunit
- Human
- Mood
- Neurosteroid
- Premenstrual dysphoric disorder PMDD
- Progesterone
- Stress
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Psychiatry and Mental health