Fyn kinase function in lipid utilization: A new upstream regulator of AMPK activity?

Manu Vatish; Eijiro Yamada; Jeffrey E. Pessin; Claire C. Bastie

doi:10.1080/13813450903164348

Fyn kinase function in lipid utilization: A new upstream regulator of AMPK activity?

Manu Vatish
, Eijiro Yamada
, Jeffrey E. Pessin
, Claire C. Bastie

Medicine

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

The balance of cellular energy levels in response to changes of nutrient availability, stress stimuli or exercise is a critical step in maintaining tissue and whole body homeostasis. Disruption of this balance is associated with various pathologies, including the metabolic syndrome. Recently, accumulating evidence has demonstrated that the AMP-activated protein kinase (AMPK) plays a central role in sensing changes in energy levels. The regulation of AMPK activity is currently the subject of significant investigation since this enzyme is a potential therapeutic target in both metabolic disorders and tumorigenesis. In this review, we present novel evidence of crosstalk between Fyn, one member of the Src kinase family, and AMPK.

Original language	English (US)
Pages (from-to)	191-198
Number of pages	8
Journal	Archives of Physiology and Biochemistry
Volume	115
Issue number	4
DOIs	https://doi.org/10.1080/13813450903164348
State	Published - Oct 2009

Keywords

AMPK
Fyn kinase
Homeostasis
LKB1
Lipid metabolism

ASJC Scopus subject areas

Physiology
Physiology (medical)

Access to Document

10.1080/13813450903164348

Cite this

@article{10412ba8d76547f591532651121ab8f8,

title = "Fyn kinase function in lipid utilization: A new upstream regulator of AMPK activity?",

abstract = "The balance of cellular energy levels in response to changes of nutrient availability, stress stimuli or exercise is a critical step in maintaining tissue and whole body homeostasis. Disruption of this balance is associated with various pathologies, including the metabolic syndrome. Recently, accumulating evidence has demonstrated that the AMP-activated protein kinase (AMPK) plays a central role in sensing changes in energy levels. The regulation of AMPK activity is currently the subject of significant investigation since this enzyme is a potential therapeutic target in both metabolic disorders and tumorigenesis. In this review, we present novel evidence of crosstalk between Fyn, one member of the Src kinase family, and AMPK.",

keywords = "AMPK, Fyn kinase, Homeostasis, LKB1, Lipid metabolism",

author = "Manu Vatish and Eijiro Yamada and Pessin, \{Jeffrey E.\} and Bastie, \{Claire C.\}",

note = "Funding Information: This work was supported by The Ellison Medical Foundation (New Scholars Award in Aging) (CB), the National Institutes of Health (DK78886, DK20541, DK020541) and the American Diabetes Association (1-07-RA-142) (JP). MV is grateful to the Fulbright Commission for support.",

year = "2009",

month = oct,

doi = "10.1080/13813450903164348",

language = "English (US)",

volume = "115",

pages = "191--198",

journal = "Archives of Physiology and Biochemistry",

issn = "1381-3455",

publisher = "Taylor and Francis Ltd.",

number = "4",

}

TY - JOUR

T1 - Fyn kinase function in lipid utilization

T2 - A new upstream regulator of AMPK activity?

AU - Vatish, Manu

AU - Yamada, Eijiro

AU - Pessin, Jeffrey E.

AU - Bastie, Claire C.

N1 - Funding Information: This work was supported by The Ellison Medical Foundation (New Scholars Award in Aging) (CB), the National Institutes of Health (DK78886, DK20541, DK020541) and the American Diabetes Association (1-07-RA-142) (JP). MV is grateful to the Fulbright Commission for support.

PY - 2009/10

Y1 - 2009/10

N2 - The balance of cellular energy levels in response to changes of nutrient availability, stress stimuli or exercise is a critical step in maintaining tissue and whole body homeostasis. Disruption of this balance is associated with various pathologies, including the metabolic syndrome. Recently, accumulating evidence has demonstrated that the AMP-activated protein kinase (AMPK) plays a central role in sensing changes in energy levels. The regulation of AMPK activity is currently the subject of significant investigation since this enzyme is a potential therapeutic target in both metabolic disorders and tumorigenesis. In this review, we present novel evidence of crosstalk between Fyn, one member of the Src kinase family, and AMPK.

AB - The balance of cellular energy levels in response to changes of nutrient availability, stress stimuli or exercise is a critical step in maintaining tissue and whole body homeostasis. Disruption of this balance is associated with various pathologies, including the metabolic syndrome. Recently, accumulating evidence has demonstrated that the AMP-activated protein kinase (AMPK) plays a central role in sensing changes in energy levels. The regulation of AMPK activity is currently the subject of significant investigation since this enzyme is a potential therapeutic target in both metabolic disorders and tumorigenesis. In this review, we present novel evidence of crosstalk between Fyn, one member of the Src kinase family, and AMPK.

KW - AMPK

KW - Fyn kinase

KW - Homeostasis

KW - LKB1

KW - Lipid metabolism

UR - https://www.scopus.com/pages/publications/70449365855

UR - https://www.scopus.com/pages/publications/70449365855#tab=citedBy

U2 - 10.1080/13813450903164348

DO - 10.1080/13813450903164348

M3 - Review article

C2 - 19728795

AN - SCOPUS:70449365855

SN - 1381-3455

VL - 115

SP - 191

EP - 198

JO - Archives of Physiology and Biochemistry

JF - Archives of Physiology and Biochemistry

IS - 4

ER -

Fyn kinase function in lipid utilization: A new upstream regulator of AMPK activity?

Abstract

Keywords

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