Fungal melanin and the Mammalian immune system

Sichen Liu, Sirida Youngchim, Daniel Zamith-Miranda, Joshua D. Nosanchuk

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Melanins are ubiquitous complex polymers that are commonly known in humans to cause pigmentation of our skin. Melanins are also present in bacteria, fungi, and helminths. In this review, we will describe the diverse interactions of fungal melanin with the mammalian immune system. We will particularly focus on Cryptococcus neoformans and also discuss other major melanotic pathogenic fungi. Melanin interacts with the immune system through diverse pathways, reducing the effectiveness of phagocytic cells, binding effector molecules and antifungals, and modifying complement and antibody responses.

Original languageEnglish (US)
Article number264
JournalJournal of Fungi
Issue number4
StatePublished - 2021


  • Fungus
  • Immune response
  • Melanin
  • Yeast

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Plant Science
  • Microbiology (medical)


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