Functional role of miR-34a in diabetes and frailty

Pasquale Mone; Antonio de Donato; Fahimeh Varzideh; Urna Kansakar; Stanislovas S. Jankauskas; Antonella Pansini; Gaetano Santulli

doi:10.3389/fragi.2022.949924

Functional role of miR-34a in diabetes and frailty

Pasquale Mone
, Antonio de Donato
, Fahimeh Varzideh
, Urna Kansakar
, Stanislovas S. Jankauskas
, Antonella Pansini
, Gaetano Santulli

Medicine

Research output: Contribution to journal › Short survey › peer-review

17 Scopus citations

Abstract

Emerging evidence has shown that microRNAs (miRNAs) play critical role in the pathogenesis of several disorders. In the present minireview, we focus our attention on the functional role of a specific miRNA, namely miR-34a, in the pathophysiology of frailty and diabetes mellitus. Based on the current literature, we speculate that this miRNA may serve as a potential biomarker of frailty in diabetic older adults. Additionally, its actions on oxidative stress might represent a druggable target to obtain new potentials treatments.

Original language	English (US)
Article number	949924
Journal	Frontiers in Aging
Volume	3
DOIs	https://doi.org/10.3389/fragi.2022.949924
State	Published - 2022

Keywords

aging
diabetes
frailty
miR-34
miRNA

ASJC Scopus subject areas

Aging
Genetics
Molecular Biology
Physiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fragi.2022.949924

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title = "Functional role of miR-34a in diabetes and frailty",

abstract = "Emerging evidence has shown that microRNAs (miRNAs) play critical role in the pathogenesis of several disorders. In the present minireview, we focus our attention on the functional role of a specific miRNA, namely miR-34a, in the pathophysiology of frailty and diabetes mellitus. Based on the current literature, we speculate that this miRNA may serve as a potential biomarker of frailty in diabetic older adults. Additionally, its actions on oxidative stress might represent a druggable target to obtain new potentials treatments.",

keywords = "aging, diabetes, frailty, miR-34, miRNA",

author = "Pasquale Mone and \{de Donato\}, Antonio and Fahimeh Varzideh and Urna Kansakar and Jankauskas, \{Stanislovas S.\} and Antonella Pansini and Gaetano Santulli",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Mone, de Donato, Varzideh, Kansakar, Jankauskas, Pansini and Santulli.",

year = "2022",

doi = "10.3389/fragi.2022.949924",

language = "English (US)",

volume = "3",

journal = "Frontiers in Aging",

issn = "2673-6217",

publisher = "Frontiers Media SA",

}

TY - JOUR

T1 - Functional role of miR-34a in diabetes and frailty

AU - Mone, Pasquale

AU - de Donato, Antonio

AU - Varzideh, Fahimeh

AU - Kansakar, Urna

AU - Jankauskas, Stanislovas S.

AU - Pansini, Antonella

AU - Santulli, Gaetano

PY - 2022

Y1 - 2022

N2 - Emerging evidence has shown that microRNAs (miRNAs) play critical role in the pathogenesis of several disorders. In the present minireview, we focus our attention on the functional role of a specific miRNA, namely miR-34a, in the pathophysiology of frailty and diabetes mellitus. Based on the current literature, we speculate that this miRNA may serve as a potential biomarker of frailty in diabetic older adults. Additionally, its actions on oxidative stress might represent a druggable target to obtain new potentials treatments.

AB - Emerging evidence has shown that microRNAs (miRNAs) play critical role in the pathogenesis of several disorders. In the present minireview, we focus our attention on the functional role of a specific miRNA, namely miR-34a, in the pathophysiology of frailty and diabetes mellitus. Based on the current literature, we speculate that this miRNA may serve as a potential biomarker of frailty in diabetic older adults. Additionally, its actions on oxidative stress might represent a druggable target to obtain new potentials treatments.

KW - aging

KW - diabetes

KW - frailty

KW - miR-34

KW - miRNA

UR - https://www.scopus.com/pages/publications/85138777447

UR - https://www.scopus.com/pages/publications/85138777447#tab=citedBy

U2 - 10.3389/fragi.2022.949924

DO - 10.3389/fragi.2022.949924

M3 - Short survey

AN - SCOPUS:85138777447

SN - 2673-6217

VL - 3

JO - Frontiers in Aging

JF - Frontiers in Aging

M1 - 949924

ER -

Functional role of miR-34a in diabetes and frailty

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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