Functional Role of microRNAs in Regulating Cardiomyocyte Death

Urna Kansakar; Fahimeh Varzideh; Pasquale Mone; Stanislovas S. Jankauskas; Gaetano Santulli

doi:10.3390/cells11060983

Functional Role of microRNAs in Regulating Cardiomyocyte Death

Urna Kansakar
, Fahimeh Varzideh
, Pasquale Mone
, Stanislovas S. Jankauskas
, Gaetano Santulli

Medicine

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numer-ous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.

Original language	English (US)
Article number	983
Journal	Cells
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/cells11060983
State	Published - Mar 1 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apoptosis
Autophagy
Cardiomyocytes
Cell death
Heart failure
Ischemia/reperfusion
Myocardial infarction
Necrosis
Non-coding RNA

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3390/cells11060983

Cite this

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title = "Functional Role of microRNAs in Regulating Cardiomyocyte Death",

abstract = "microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numer-ous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.",

keywords = "Apoptosis, Autophagy, Cardiomyocytes, Cell death, Heart failure, Ischemia/reperfusion, Myocardial infarction, Necrosis, Non-coding RNA",

author = "Urna Kansakar and Fahimeh Varzideh and Pasquale Mone and Jankauskas, \{Stanislovas S.\} and Gaetano Santulli",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = mar,

day = "1",

doi = "10.3390/cells11060983",

language = "English (US)",

volume = "11",

journal = "Cells",

issn = "2073-4409",

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TY - JOUR

T1 - Functional Role of microRNAs in Regulating Cardiomyocyte Death

AU - Kansakar, Urna

AU - Varzideh, Fahimeh

AU - Mone, Pasquale

AU - Jankauskas, Stanislovas S.

AU - Santulli, Gaetano

PY - 2022/3/1

Y1 - 2022/3/1

N2 - microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numer-ous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.

AB - microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numer-ous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.

KW - Apoptosis

KW - Autophagy

KW - Cardiomyocytes

KW - Cell death

KW - Heart failure

KW - Ischemia/reperfusion

KW - Myocardial infarction

KW - Necrosis

KW - Non-coding RNA

UR - https://www.scopus.com/pages/publications/85126317981

UR - https://www.scopus.com/pages/publications/85126317981#tab=citedBy

U2 - 10.3390/cells11060983

DO - 10.3390/cells11060983

M3 - Review article

C2 - 35326433

AN - SCOPUS:85126317981

SN - 2073-4409

VL - 11

JO - Cells

JF - Cells

IS - 6

M1 - 983

ER -

Functional Role of microRNAs in Regulating Cardiomyocyte Death

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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