@article{e3af5da607ee4f67bda8c682fa9c708e,
title = "Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins",
abstract = "Genome-scale CRISPR gene editing studies by Shirasaki et al. reveal which genes confer myeloma cell resistance to PROTACs that leverage different E3 ligases to degrade various oncoproteins. The study provides a framework for sequential/alternating versus combined use of PROTACs, depending on which E3 ligase and oncoprotein they engage.",
keywords = "CRBN, CRISPR, CRISPR activation, E3 ligase, PROTAC, VHL, heterobifunctional proteolysis-targeting chimeric compounds, myeloma, pharmacological degraders, resistance",
author = "Ryosuke Shirasaki and Matthews, {Geoffrey M.} and Sara Gandolfi and {de Matos Simoes}, Ricardo and Buckley, {Dennis L.} and {Raja Vora}, Joseline and Sievers, {Quinlan L.} and Br{\"u}ggenthies, {Johanna B.} and Olga Dashevsky and Haley Poarch and Huihui Tang and Bariteau, {Megan A.} and Michal Sheffer and Yiguo Hu and Downey-Kopyscinski, {Sondra L.} and Hengeveld, {Paul J.} and Glassner, {Brian J.} and Eugen Dhimolea and Ott, {Christopher J.} and Tinghu Zhang and Kwiatkowski, {Nicholas P.} and Laubach, {Jacob P.} and Schlossman, {Robert L.} and Richardson, {Paul G.} and Culhane, {Aedin C.} and Groen, {Richard W.J.} and Fischer, {Eric S.} and Francisca Vazquez and Aviad Tsherniak and Hahn, {William C.} and Joan Levy and Daniel Auclair and Licht, {Jonathan D.} and Keats, {Jonathan J.} and Boise, {Lawrence H.} and Ebert, {Benjamin L.} and Bradner, {James E.} and Gray, {Nathanael S.} and Mitsiades, {Constantine S.}",
note = "Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2021",
month = jan,
day = "5",
doi = "10.1016/j.celrep.2020.108532",
language = "English (US)",
volume = "34",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",
}