Abstract
T cell activation and function require a structured engagement of antigen-presenting cells. These cell contacts are characterized by two distinct dynamics in vivo: transient contacts resulting from promigratory junctions called immunological kinapses or prolonged contacts from stable junctions called immunological synapses. Kinapses operate in the steady state to allow referencing to self-peptide-MHC (pMHC) and searching for pathogen-derived pMHC. Synapses are induced by T cell receptor (TCR) interactions with agonist pMHC under specific conditions and correlate with robust immune responses that generate effector and memory T cells. High-resolution imaging has revealed that the synapse is highly coordinated, integrating cell adhesion, TCR recognition of pMHC complexes, and an array of activating and inhibitory ligands to promote or prevent T cell signaling. In this review, we examine the molecular components, geometry, and timing underlying kinapses and synapses. We integrate recent molecular and physiological data to provide a synthesis and suggest ways forward.
Original language | English (US) |
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Pages (from-to) | 79-105 |
Number of pages | 27 |
Journal | Annual Review of Immunology |
Volume | 28 |
DOIs | |
State | Published - Apr 23 2010 |
Externally published | Yes |
Keywords
- Immunological synapse
- Kinapse
- Microcluster
- TCR triggering
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology