Fluoxetine treatment of anger attacks: A replication study

Maurizio Fava, Jonathan Alpert, Andrew A. Nierenberg, Nassir Ghaemi, Richard O'Sullivan, Joyce Tedlow, John Worthington, Jerrold F. Rosenbaum

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


'Anger attacks' are outbursts of anger which are accompanied by intense autonomic arousal and are clearly inappropriate to the situation in which they occur. The Anger Attacks Questionnaire, designed to assess these attacks, was administered to 164 consecutive patients (78 men and 86 women; mean age, 40.5 ± 11.0 years) diagnosed as having major depression with the Structured Clinical Interview for DSM-III-R. These patients were treated openly with fluoxetine, 20 mg/day for 8 weeks, and the prevalence of anger attacks was assessed before and after treatment. At baseline, 64 (39%) (26 men and 38 women) of these patients reported having anger attacks according to our criteria. Forty-one (64%) of the 64 depressed patients with anger attacks at baseline did not report anger attacks following fluoxetine treatment, while 7 (7%) of the 100 patients who did not have anger attacks at baseline reported these attacks following treatment, with this difference being statistically significant (χ2 = 22.7, p < .0005).

Original languageEnglish (US)
Pages (from-to)7-10
Number of pages4
JournalAnnals of Clinical Psychiatry
Issue number1
StatePublished - Mar 1996
Externally publishedYes


  • Anger attacks
  • Antidepressant treatment
  • Depression
  • Fluoxetine

ASJC Scopus subject areas

  • Psychiatry and Mental health


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