Ferroptosis as an emerging target in sickle cell disease

Vitor Fortuna; Jaqueline Lima; Gabriel F. Oliveira; Yasmin S. Oliveira; Bruk Getachew; Sergei Nekhai; Michael Aschner; Yousef Tizabi

doi:10.1016/j.crtox.2024.100181

Ferroptosis as an emerging target in sickle cell disease

Vitor Fortuna, Jaqueline Lima, Gabriel F. Oliveira, Yasmin S. Oliveira, Bruk Getachew, Sergei Nekhai, Michael Aschner, Yousef Tizabi

Molecular Pharmacology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood cell sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of cell death characterized by reactive oxygen species (ROS) and lipid peroxide accumulation, leading to damage and organ impairments. The intricate interplay between iron, ferroptosis, inflammation, and oxidative stress in SCD underscores the necessity of thoroughly understanding these processes for the development of innovative therapeutic strategies. This review highlights the importance of balancing the complex interactions among various factors and exploitation of the knowledge in developing novel therapeutics for this devastating disease.

Original language	English (US)
Article number	100181
Journal	Current Research in Toxicology
Volume	7
DOIs	https://doi.org/10.1016/j.crtox.2024.100181
State	Published - Jan 2024

Keywords

Ferroptosis
Iron toxicity
Lipid peroxidation
Novel targets
Oxidative stress
Sickle cell disease

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Toxicology
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.crtox.2024.100181

Cite this

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title = "Ferroptosis as an emerging target in sickle cell disease",

abstract = "Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood cell sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of cell death characterized by reactive oxygen species (ROS) and lipid peroxide accumulation, leading to damage and organ impairments. The intricate interplay between iron, ferroptosis, inflammation, and oxidative stress in SCD underscores the necessity of thoroughly understanding these processes for the development of innovative therapeutic strategies. This review highlights the importance of balancing the complex interactions among various factors and exploitation of the knowledge in developing novel therapeutics for this devastating disease.",

keywords = "Ferroptosis, Iron toxicity, Lipid peroxidation, Novel targets, Oxidative stress, Sickle cell disease",

author = "Vitor Fortuna and Jaqueline Lima and Oliveira, {Gabriel F.} and Oliveira, {Yasmin S.} and Bruk Getachew and Sergei Nekhai and Michael Aschner and Yousef Tizabi",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",

year = "2024",

month = jan,

doi = "10.1016/j.crtox.2024.100181",

language = "English (US)",

volume = "7",

journal = "Current Research in Toxicology",

issn = "2666-027X",

publisher = "Elsevier B.V.",

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T1 - Ferroptosis as an emerging target in sickle cell disease

AU - Fortuna, Vitor

AU - Lima, Jaqueline

AU - Oliveira, Gabriel F.

AU - Oliveira, Yasmin S.

AU - Getachew, Bruk

AU - Nekhai, Sergei

AU - Aschner, Michael

AU - Tizabi, Yousef

PY - 2024/1

Y1 - 2024/1

N2 - Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood cell sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of cell death characterized by reactive oxygen species (ROS) and lipid peroxide accumulation, leading to damage and organ impairments. The intricate interplay between iron, ferroptosis, inflammation, and oxidative stress in SCD underscores the necessity of thoroughly understanding these processes for the development of innovative therapeutic strategies. This review highlights the importance of balancing the complex interactions among various factors and exploitation of the knowledge in developing novel therapeutics for this devastating disease.

AB - Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood cell sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of cell death characterized by reactive oxygen species (ROS) and lipid peroxide accumulation, leading to damage and organ impairments. The intricate interplay between iron, ferroptosis, inflammation, and oxidative stress in SCD underscores the necessity of thoroughly understanding these processes for the development of innovative therapeutic strategies. This review highlights the importance of balancing the complex interactions among various factors and exploitation of the knowledge in developing novel therapeutics for this devastating disease.

KW - Ferroptosis

KW - Iron toxicity

KW - Lipid peroxidation

KW - Novel targets

KW - Oxidative stress

KW - Sickle cell disease

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Ferroptosis as an emerging target in sickle cell disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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