Feline immunodeficiency virus (FIV) in wild Pallas' cats

Meredith A. Brown, Bariushaa Munkhtsog, Jennifer L. Troyer, Steve Ross, Rani Sellers, Amanda E. Fine, William F. Swanson, Melody E. Roelke, Stephen J. O'Brien

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic and wild cats. The Pallas' cat is the only species from Asia known to harbor a species-specific strain of FIV designated FIVOma in natural populations. Here, a 25% seroprevalence of FIV is reported from 28 wild Mongolian Pallas' cats sampled from 2000 to 2008. Phylogenetic analysis of proviral RT-Pol from eight FIVOma isolates from Mongolia, Russia, China and Kazakhstan reveals a unique monophyletic lineage of the virus within the Pallas' cat population, most closely related to the African cheetah and leopard FIV strains. Histopathological examination of lymph node and spleen from infected and uninfected Pallas' cats suggests that FIVOma causes immune depletion in its' native host.

Original languageEnglish (US)
Pages (from-to)90-95
Number of pages6
JournalVeterinary Immunology and Immunopathology
Issue number1-2
StatePublished - Mar 15 2010


  • Evolution
  • FIV
  • Felidae
  • Histopathology
  • Pallas' cat

ASJC Scopus subject areas

  • Immunology
  • General Veterinary


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