TY - JOUR
T1 - Failure of ketoconazole as anti-androgen therapy in nonresectable primary hepatocellular carcinoma
AU - Gupta, Sanjeev
AU - Korula, Jacob
PY - 1988/12
Y1 - 1988/12
N2 - Lacking a treatment for nonresectable hepatocellular carcinoma (HCC), we have utilized the androgen antagonist properties of ketoconazole in treating eight patients, seven men and one woman, with HCC, which, in view of a higher prevalence of HCC in men, seems to be androgen dependent. Response to treatment was determined by grading symptoms, serum alphafetoprotein, alteration in tumor size, and duration of survival. No patient had any significant side-effects from ketoconazole. No symptomatic improvement occurred, percent tumor size increased from 38.6 ± 12, mean ± SEM, to 44.4 ± 12, and mean survival in six patients who were followed until death was less than 8 weeks from diagnosis. Anti-androgenic therapy with ketoconazole was not effective in any of these patients.
AB - Lacking a treatment for nonresectable hepatocellular carcinoma (HCC), we have utilized the androgen antagonist properties of ketoconazole in treating eight patients, seven men and one woman, with HCC, which, in view of a higher prevalence of HCC in men, seems to be androgen dependent. Response to treatment was determined by grading symptoms, serum alphafetoprotein, alteration in tumor size, and duration of survival. No patient had any significant side-effects from ketoconazole. No symptomatic improvement occurred, percent tumor size increased from 38.6 ± 12, mean ± SEM, to 44.4 ± 12, and mean survival in six patients who were followed until death was less than 8 weeks from diagnosis. Anti-androgenic therapy with ketoconazole was not effective in any of these patients.
KW - Androgen antagonist
KW - Anti-androgen
KW - Hepatocellular carcinoma
KW - Ketoconazole
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U2 - 10.1097/00004836-198812000-00016
DO - 10.1097/00004836-198812000-00016
M3 - Article
C2 - 2466073
AN - SCOPUS:0024231232
SN - 0192-0790
VL - 10
SP - 651
EP - 654
JO - Journal of clinical gastroenterology
JF - Journal of clinical gastroenterology
IS - 6
ER -