Failure of estradiol to ameliorate global ischemia-induced CA1 sector injury in middle-aged female gerbils

Maxine De Butte-Smith, Angela P. Nguyen, R. Suzanne Zukin, Anne M. Etgen, Frederick Colbourne

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Global forebrain ischemia arising from brief occlusion of the carotid arteries in gerbils produces selective hippocampal CA1 neuronal loss. Pre-treatment with 17β-estradiol ameliorates, in part, ischemia-induced damage in young animals. Because stroke and cardiac arrest are more likely to occur among elderly individuals, neuroprotective studies in older animals have compelling clinical relevance. We investigated whether estradiol would attenuate ischemia-induced hippocampal neuronal injury in middle-aged (12-14 months) male, intact female, ovariectomized (OVX) female and OVX females treated for 14 days with estradiol. Core temperature telemetry probes were also implanted at the time that estradiol was initiated. Ischemia was induced by bilateral occlusion of the common carotid arteries (5 min), during which time skull temperature was maintained under normothermic conditions. Estradiol blocked the modest spontaneous hyperthermia that normally follows ischemia. However, all four groups exhibited substantial neuronal cell loss in the CA1, assessed at 7 after ischemia. These findings indicate that estradiol pre-treatment under conditions that produce neuroprotection in young animals does not protect against ischemia-induced CA1 cell loss in middle-aged female gerbils.

Original languageEnglish (US)
Pages (from-to)214-220
Number of pages7
JournalBrain research
Issue number1
StatePublished - Jun 11 2007


  • Brain temperature
  • Hippocampus
  • Hyperactivity
  • Neuroprotection

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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