Extensive apoptosis in a case of intractable infantile status epilepticus

Koshi A. Cherian; Karen Weidenheim; Alan D. Legatt; Keivan Shifteh; I. Richmond Abbott; Solomon L. Moshé

doi:10.1016/j.eplepsyres.2009.03.009

Extensive apoptosis in a case of intractable infantile status epilepticus

Koshi A. Cherian, Karen Weidenheim, Alan D. Legatt, Keivan Shifteh, I. Richmond Abbott, Solomon L. Moshé

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A previously healthy 81/2-month-old girl underwent epilepsy surgery for intractable focal seizures with secondary generalization that progressed to status epilepticus. The major neuropathologic finding was extensive apoptosis. Investigations did not reveal any etiology for the apoptosis or the seizures. This is the first report of apoptosis, without necrosis, in association with intractable status epilepticus in the developing human brain. The findings suggest that new treatment strategies targeted to prevent apoptosis may be useful in children with prolonged status epilepticus.

Original language	English (US)
Pages (from-to)	305-310
Number of pages	6
Journal	Epilepsy Research
Volume	85
Issue number	2-3
DOIs	https://doi.org/10.1016/j.eplepsyres.2009.03.009
State	Published - Aug 2009

Keywords

Apoptosis
Epilepsy surgery
Infant
Status epilepticus

ASJC Scopus subject areas

Neurology
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.eplepsyres.2009.03.009

Cite this

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title = "Extensive apoptosis in a case of intractable infantile status epilepticus",

abstract = "A previously healthy 81/2-month-old girl underwent epilepsy surgery for intractable focal seizures with secondary generalization that progressed to status epilepticus. The major neuropathologic finding was extensive apoptosis. Investigations did not reveal any etiology for the apoptosis or the seizures. This is the first report of apoptosis, without necrosis, in association with intractable status epilepticus in the developing human brain. The findings suggest that new treatment strategies targeted to prevent apoptosis may be useful in children with prolonged status epilepticus.",

keywords = "Apoptosis, Epilepsy surgery, Infant, Status epilepticus",

author = "Cherian, {Koshi A.} and Karen Weidenheim and Legatt, {Alan D.} and Keivan Shifteh and Abbott, {I. Richmond} and Mosh{\'e}, {Solomon L.}",

note = "Funding Information: This work was supported by the Heffer Family Medical Foundation. Dr. S.L. Mosh{\'e} is the recipient of the Martin A. and Emily L. Fisher Fellowship in Neurology and Pediatrics. ",

year = "2009",

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doi = "10.1016/j.eplepsyres.2009.03.009",

language = "English (US)",

volume = "85",

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journal = "Epilepsy Research",

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T1 - Extensive apoptosis in a case of intractable infantile status epilepticus

AU - Cherian, Koshi A.

AU - Weidenheim, Karen

AU - Legatt, Alan D.

AU - Shifteh, Keivan

AU - Abbott, I. Richmond

AU - Moshé, Solomon L.

N1 - Funding Information: This work was supported by the Heffer Family Medical Foundation. Dr. S.L. Moshé is the recipient of the Martin A. and Emily L. Fisher Fellowship in Neurology and Pediatrics.

PY - 2009/8

Y1 - 2009/8

N2 - A previously healthy 81/2-month-old girl underwent epilepsy surgery for intractable focal seizures with secondary generalization that progressed to status epilepticus. The major neuropathologic finding was extensive apoptosis. Investigations did not reveal any etiology for the apoptosis or the seizures. This is the first report of apoptosis, without necrosis, in association with intractable status epilepticus in the developing human brain. The findings suggest that new treatment strategies targeted to prevent apoptosis may be useful in children with prolonged status epilepticus.

AB - A previously healthy 81/2-month-old girl underwent epilepsy surgery for intractable focal seizures with secondary generalization that progressed to status epilepticus. The major neuropathologic finding was extensive apoptosis. Investigations did not reveal any etiology for the apoptosis or the seizures. This is the first report of apoptosis, without necrosis, in association with intractable status epilepticus in the developing human brain. The findings suggest that new treatment strategies targeted to prevent apoptosis may be useful in children with prolonged status epilepticus.

KW - Apoptosis

KW - Epilepsy surgery

KW - Infant

KW - Status epilepticus

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ER -

Extensive apoptosis in a case of intractable infantile status epilepticus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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