Extensive apoptosis in a case of intractable infantile status epilepticus

Koshi A. Cherian, Karen Weidenheim, Alan D. Legatt, Keivan Shifteh, I. Richmond Abbott, Solomon L. Moshé

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


A previously healthy 81/2-month-old girl underwent epilepsy surgery for intractable focal seizures with secondary generalization that progressed to status epilepticus. The major neuropathologic finding was extensive apoptosis. Investigations did not reveal any etiology for the apoptosis or the seizures. This is the first report of apoptosis, without necrosis, in association with intractable status epilepticus in the developing human brain. The findings suggest that new treatment strategies targeted to prevent apoptosis may be useful in children with prolonged status epilepticus.

Original languageEnglish (US)
Pages (from-to)305-310
Number of pages6
JournalEpilepsy Research
Issue number2-3
StatePublished - Aug 2009


  • Apoptosis
  • Epilepsy surgery
  • Infant
  • Status epilepticus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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