Expression of a myeloid marker on TdT-positive acute lymphocytic leukemic cells: Evidence by double-fluorescence staining

P. Bettelheim; E. Paietta; O. Majdic; H. Gadner; J. Schwarzmeier; W. Knapp

Expression of a myeloid marker on TdT-positive acute lymphocytic leukemic cells: Evidence by double-fluorescence staining

P. Bettelheim, E. Paietta, O. Majdic, H. Gadner, J. Schwarzmeier, W. Knapp

Research output: Contribution to journal › Article › peer-review

Abstract

The expression of a myeloid-specific antigen was detected on TdT-positive blast cell populations in two cases of childhood acute lymphocytic leukemia. Double-fluorescence staining by using the monoclonal antibody, VIM-D5, which is specific for cells of myeloid origin, in combination with TdT antiserum revealed that a distinct portion of the blast cell carried both markers. The finding represents the first direct demonstration of this specific biphenotype in leukemic cells and was interpreted as the abnormal expression of a myeloid antigen on lymphoid blast cells.

Original language	English (US)
Pages (from-to)	1392-1396
Number of pages	5
Journal	Blood
Volume	60
Issue number	6
State	Published - Dec 1 1982
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

Cite this

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abstract = "The expression of a myeloid-specific antigen was detected on TdT-positive blast cell populations in two cases of childhood acute lymphocytic leukemia. Double-fluorescence staining by using the monoclonal antibody, VIM-D5, which is specific for cells of myeloid origin, in combination with TdT antiserum revealed that a distinct portion of the blast cell carried both markers. The finding represents the first direct demonstration of this specific biphenotype in leukemic cells and was interpreted as the abnormal expression of a myeloid antigen on lymphoid blast cells.",

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T1 - Expression of a myeloid marker on TdT-positive acute lymphocytic leukemic cells

T2 - Evidence by double-fluorescence staining

AU - Bettelheim, P.

AU - Paietta, E.

AU - Majdic, O.

AU - Gadner, H.

AU - Schwarzmeier, J.

AU - Knapp, W.

PY - 1982/12/1

Y1 - 1982/12/1

N2 - The expression of a myeloid-specific antigen was detected on TdT-positive blast cell populations in two cases of childhood acute lymphocytic leukemia. Double-fluorescence staining by using the monoclonal antibody, VIM-D5, which is specific for cells of myeloid origin, in combination with TdT antiserum revealed that a distinct portion of the blast cell carried both markers. The finding represents the first direct demonstration of this specific biphenotype in leukemic cells and was interpreted as the abnormal expression of a myeloid antigen on lymphoid blast cells.

AB - The expression of a myeloid-specific antigen was detected on TdT-positive blast cell populations in two cases of childhood acute lymphocytic leukemia. Double-fluorescence staining by using the monoclonal antibody, VIM-D5, which is specific for cells of myeloid origin, in combination with TdT antiserum revealed that a distinct portion of the blast cell carried both markers. The finding represents the first direct demonstration of this specific biphenotype in leukemic cells and was interpreted as the abnormal expression of a myeloid antigen on lymphoid blast cells.

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JO - Blood

JF - Blood

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Expression of a myeloid marker on TdT-positive acute lymphocytic leukemic cells: Evidence by double-fluorescence staining

Abstract

ASJC Scopus subject areas

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