Expert consensus established around flexible, individualized migraine treatment utilizing a modified Delphi panel

Marlon Graf, Edward Kim, Iris Brewer, Jennifer Hernandez, Jacquelyn W. Chou, Jessica Cirillo, Christopher Jensen, Richard Lipton

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To characterize treatment decision-making processes and formalize consensus regarding key factors headache specialists consider in treatment decisions for patients with migraine, considering novel therapies. Background: Migraine therapies have long been subject to binary classification, acute versus preventive, due to limitations of available drugs. The emergence of novel therapies that can be used more flexibly creates an opportunity to rethink this binary classification. To determine the role of these novel therapies in treatment, it is critical to understand whether existing guidelines reflect clinical practice and to establish consensus around factors driving management. Methods: A three-round modified Delphi process was conducted with migraine clinical experts. Round 1 consisted of an online questionnaire; Round 2 involved an online discussion of aggregated Round 1 results; and Round 3 allowed participants to revise Round 1 responses, incorporating Round 2 insights. Questions elicited likelihood ratings (0 = highly unlikely to 100 = highly likely), rankings, and estimates on treatment decision-making. Results: Nineteen experts completed three Delphi rounds. Experts strongly agreed on definitions for “acute” (median = 100, inter-quartile range [IQR] = 5) and “preventive” treatment (median = 90, IQR = 15), but noted a need for treatment customization for patients (median = 100, IQR = 6). Experts noted certain aspects of guidelines may no longer apply based on established tolerability and efficacy of newer acute and preventive agents (median = 91, IQR = 17). Further, experts agreed on a treatment category referred to as “situational prevention” (or “short-term prevention”) for patients with reliable and predictable migraine triggers (median = 100, IQR = 10) or time-limited periods when headache avoidance is important (median = 100, IQR = 12). Conclusions: Using the modified Delphi method, a panel of migraine experts identified the importance of customizing treatment for people with migraine and the utility of “situational prevention,” given the ability of new treatment options to meet this need and the potential to clinically identify patients and time periods when this approach would add value.

Original languageEnglish (US)
Pages (from-to)506-516
Number of pages11
JournalHeadache
Volume63
Issue number4
DOIs
StatePublished - Apr 2023

Keywords

  • acute migraine therapy
  • migraine
  • migraine impact
  • outcomes research
  • prophylactic/preventive treatment

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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