EXCESP: A Structure-Based Online Database for Extracellular Interactome of Cell Surface Proteins in Humans

Kalyani Dhusia, Carlos Madrid, Zhaoqian Su, Yinghao Wu

Research output: Contribution to journalArticlepeer-review


The interactions between ectodomains of cell surface proteins are vital players in many important cellular processes, such as regulating immune responses, coordinating cell differentiation, and shaping neural plasticity. However, while the construction of a large-scale protein interactome has been greatly facilitated by the development of high-throughput experimental techniques, little progress has been made to support the discovery of extracellular interactome for cell surface proteins. Harnessed by the recent advances in computational modeling of protein-protein interactions, here we present a structure-based online database for the extracellular interactome of cell surface proteins in humans, called EXCESP. The database contains both experimentally determined and computationally predicted interactions among all type-I transmembrane proteins in humans. All structural models for these interactions and their binding affinities were further computationally modeled. Moreover, information such as expression levels of each protein in different cell types and its relation to various signaling pathways from other online resources has also been integrated into the database. In summary, the database serves as a valuable addition to the existing online resources for the study of cell surface proteins. It can contribute to the understanding of the functions of cell surface proteins in the era of systems biology.

Original languageEnglish (US)
Pages (from-to)349-359
Number of pages11
JournalJournal of Proteome Research
Issue number2
StatePublished - Feb 4 2022


  • cell surface proteins
  • computational modeling
  • extracellular interactome
  • online database
  • systems biology

ASJC Scopus subject areas

  • Biochemistry
  • General Chemistry


Dive into the research topics of 'EXCESP: A Structure-Based Online Database for Extracellular Interactome of Cell Surface Proteins in Humans'. Together they form a unique fingerprint.

Cite this