Evolution of heart transplant donor characteristics in the 21st century: A United States single center's experience

Research output: Contribution to journalReview articlepeer-review

Abstract

Despite a record setting number of heart transplants performed annually, the national donor shortage continues to plague transplant teams across the United States. Here we describe the barriers to adaptation of numerous “non-traditional” orthotopic heart transplant donor characteristics including donors with hepatitis C virus, those meeting criteria for donation after cardiac death, donors with coronavirus disease 19 infection, donors with the human immunodeficiency virus, and grafts with left ventricular systolic dysfunction. Our center's objective was to increase our transplant volume by expanding our donor pool from “traditional” donors to these “non-traditional” donors. We detail how medical advances such as certain laboratory studies, pharmacologic interventions, and organ care systems have allowed our center to expand the donor pool thereby increasing transplantation volume without adverse effects on outcomes.

Original languageEnglish (US)
Article number92721
JournalWorld Journal of Transplantation
Volume14
Issue number3
DOIs
StatePublished - Sep 18 2024

Keywords

  • COVID-19
  • Donation after cardiac death
  • Hepatitis C virus
  • Human immunodeficiency virus
  • Left ventricular systolic dysfunction
  • Orthotopic heart transplantation

ASJC Scopus subject areas

  • Transplantation

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