TY - JOUR
T1 - Evolution of heart transplant donor characteristics in the 21st century
T2 - A United States single center's experience
AU - Spring, Alexander M.
AU - Gjelaj, Christiana
AU - Madan, Shivank
AU - Patel, Snehal R.
AU - Saeed, Omar
AU - Murthy, Sandhya
AU - Rochlani, Yogita
AU - Sims, Daniel B.
AU - Vukelic, Sasha
AU - Forest, Stephen J.
AU - Borgi, Jamil F.
AU - Goldstein, Daniel J.
AU - Jorde, Ulrich P.
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/9/18
Y1 - 2024/9/18
N2 - Despite a record setting number of heart transplants performed annually, the national donor shortage continues to plague transplant teams across the United States. Here we describe the barriers to adaptation of numerous “non-traditional” orthotopic heart transplant donor characteristics including donors with hepatitis C virus, those meeting criteria for donation after cardiac death, donors with coronavirus disease 19 infection, donors with the human immunodeficiency virus, and grafts with left ventricular systolic dysfunction. Our center's objective was to increase our transplant volume by expanding our donor pool from “traditional” donors to these “non-traditional” donors. We detail how medical advances such as certain laboratory studies, pharmacologic interventions, and organ care systems have allowed our center to expand the donor pool thereby increasing transplantation volume without adverse effects on outcomes.
AB - Despite a record setting number of heart transplants performed annually, the national donor shortage continues to plague transplant teams across the United States. Here we describe the barriers to adaptation of numerous “non-traditional” orthotopic heart transplant donor characteristics including donors with hepatitis C virus, those meeting criteria for donation after cardiac death, donors with coronavirus disease 19 infection, donors with the human immunodeficiency virus, and grafts with left ventricular systolic dysfunction. Our center's objective was to increase our transplant volume by expanding our donor pool from “traditional” donors to these “non-traditional” donors. We detail how medical advances such as certain laboratory studies, pharmacologic interventions, and organ care systems have allowed our center to expand the donor pool thereby increasing transplantation volume without adverse effects on outcomes.
KW - COVID-19
KW - Donation after cardiac death
KW - Hepatitis C virus
KW - Human immunodeficiency virus
KW - Left ventricular systolic dysfunction
KW - Orthotopic heart transplantation
UR - http://www.scopus.com/inward/record.url?scp=85201127350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85201127350&partnerID=8YFLogxK
U2 - 10.5500/wjt.v14.i3.92721
DO - 10.5500/wjt.v14.i3.92721
M3 - Review article
AN - SCOPUS:85201127350
SN - 2220-3230
VL - 14
JO - World Journal of Transplantation
JF - World Journal of Transplantation
IS - 3
M1 - 92721
ER -