Evidence for the involvement of nigral GABAA receptors in seizures of adult rats

E. F. Sperber; J. N.D. Wurpel; D. Y. Zhao; S. L. Moshé

doi:10.1016/0006-8993(89)90211-4

Evidence for the involvement of nigral GABA_A receptors in seizures of adult rats

E. F. Sperber, J. N.D. Wurpel, D. Y. Zhao, S. L. Moshé

Neurology

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Several studies have implicated the substantia nigra GABAergic system in the mediation of seizures in adult rats. The present study examines whether the different GABA receptors (GABA_A and GABA_B), are preferentially involved in this GABAergic seizure suppression mechanism. Adult rats were intranigrally infused with muscimol (GABA_A receptor agonist), bicuculline (GABA_A receptor antagonist) or baclofen (GABA₁ receptor agonist) and were exposed to flurothyl seizures Results indicated that while infusions of muscimol had an anticonvulsant effect, infusions of bicuculline had a proconvulsant effect. Baclofen infusions were found to have no effect on seizures. These findings suggest an involvement of the nigral GABA_A receptors in the mediation of seizures in adult rats.

Original language	English (US)
Pages (from-to)	378-382
Number of pages	5
Journal	Brain research
Volume	480
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(89)90211-4
State	Published - Feb 20 1989

Keywords

Baclofen
Bicuculline
Convulsion
Muscimol
Rat
Seizure
Substantia nigra
γ-Aminobutyric acid

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(89)90211-4

Cite this

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title = "Evidence for the involvement of nigral GABAA receptors in seizures of adult rats",

abstract = "Several studies have implicated the substantia nigra GABAergic system in the mediation of seizures in adult rats. The present study examines whether the different GABA receptors (GABAA and GABAB), are preferentially involved in this GABAergic seizure suppression mechanism. Adult rats were intranigrally infused with muscimol (GABAA receptor agonist), bicuculline (GABAA receptor antagonist) or baclofen (GABA1 receptor agonist) and were exposed to flurothyl seizures Results indicated that while infusions of muscimol had an anticonvulsant effect, infusions of bicuculline had a proconvulsant effect. Baclofen infusions were found to have no effect on seizures. These findings suggest an involvement of the nigral GABAA receptors in the mediation of seizures in adult rats.",

keywords = "Baclofen, Bicuculline, Convulsion, Muscimol, Rat, Seizure, Substantia nigra, γ-Aminobutyric acid",

author = "Sperber, {E. F.} and Wurpel, {J. N.D.} and Zhao, {D. Y.} and Mosh{\'e}, {S. L.}",

note = "Funding Information: Supported by Grants NS 20253 and R-36986 from the United Cerebral Palsy Associations.",

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doi = "10.1016/0006-8993(89)90211-4",

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AU - Sperber, E. F.

AU - Wurpel, J. N.D.

AU - Zhao, D. Y.

AU - Moshé, S. L.

N1 - Funding Information: Supported by Grants NS 20253 and R-36986 from the United Cerebral Palsy Associations.

PY - 1989/2/20

Y1 - 1989/2/20

N2 - Several studies have implicated the substantia nigra GABAergic system in the mediation of seizures in adult rats. The present study examines whether the different GABA receptors (GABAA and GABAB), are preferentially involved in this GABAergic seizure suppression mechanism. Adult rats were intranigrally infused with muscimol (GABAA receptor agonist), bicuculline (GABAA receptor antagonist) or baclofen (GABA1 receptor agonist) and were exposed to flurothyl seizures Results indicated that while infusions of muscimol had an anticonvulsant effect, infusions of bicuculline had a proconvulsant effect. Baclofen infusions were found to have no effect on seizures. These findings suggest an involvement of the nigral GABAA receptors in the mediation of seizures in adult rats.

AB - Several studies have implicated the substantia nigra GABAergic system in the mediation of seizures in adult rats. The present study examines whether the different GABA receptors (GABAA and GABAB), are preferentially involved in this GABAergic seizure suppression mechanism. Adult rats were intranigrally infused with muscimol (GABAA receptor agonist), bicuculline (GABAA receptor antagonist) or baclofen (GABA1 receptor agonist) and were exposed to flurothyl seizures Results indicated that while infusions of muscimol had an anticonvulsant effect, infusions of bicuculline had a proconvulsant effect. Baclofen infusions were found to have no effect on seizures. These findings suggest an involvement of the nigral GABAA receptors in the mediation of seizures in adult rats.

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KW - Bicuculline

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KW - Seizure

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KW - γ-Aminobutyric acid

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