TY - JOUR
T1 - Event-related potentials in an emotional go/no-go task and remission of geriatric depression
AU - Alexopoulos, George S.
AU - Murphy, Christopher F.
AU - Gunning-Dixon, Faith M.
AU - Kalayam, Balkrishna
AU - Katz, Richard
AU - Kanellopoulos, Dora
AU - Etwaroo, Glenda R.
AU - Klimstra, Sibel
AU - Foxe, John J.
PY - 2007/2
Y1 - 2007/2
N2 - Anterior cingulate integrity may be required for antidepressant response. To assess anterior cingulate processes related to treatment response, we studied error-related negativity and error positivity produced during an emotional go/no-go challenge, a task activating the rostral anterior cingulate. Twelve elderly patients with major depression, treated with escitalopram 10 mg daily, were studied. Patients who remained symptomatic after 8 weeks of treatment had larger error-related negativity and smaller error positivity amplitude compared with patients who achieved remission. The error-related negativity is elicited during conflict detection and the error positivity reflects the emotional reaction to error. Thus, these findings suggest that two distinct conflict-processing functions of the anterior cingulate are important for antidepressant response of geriatric depression.
AB - Anterior cingulate integrity may be required for antidepressant response. To assess anterior cingulate processes related to treatment response, we studied error-related negativity and error positivity produced during an emotional go/no-go challenge, a task activating the rostral anterior cingulate. Twelve elderly patients with major depression, treated with escitalopram 10 mg daily, were studied. Patients who remained symptomatic after 8 weeks of treatment had larger error-related negativity and smaller error positivity amplitude compared with patients who achieved remission. The error-related negativity is elicited during conflict detection and the error positivity reflects the emotional reaction to error. Thus, these findings suggest that two distinct conflict-processing functions of the anterior cingulate are important for antidepressant response of geriatric depression.
KW - Depression
KW - Electroencephalogram
KW - Error-related negativity
KW - Event-related potential
KW - Geriatric
KW - Treatment response
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U2 - 10.1097/WNR.0b013e328013ceda
DO - 10.1097/WNR.0b013e328013ceda
M3 - Article
C2 - 17314660
AN - SCOPUS:33847175160
SN - 0959-4965
VL - 18
SP - 217
EP - 221
JO - NeuroReport
JF - NeuroReport
IS - 3
ER -