Event-related potentials in an emotional go/no-go task and remission of geriatric depression

George S. Alexopoulos, Christopher F. Murphy, Faith M. Gunning-Dixon, Balkrishna Kalayam, Richard Katz, Dora Kanellopoulos, Glenda R. Etwaroo, Sibel Klimstra, John J. Foxe

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Anterior cingulate integrity may be required for antidepressant response. To assess anterior cingulate processes related to treatment response, we studied error-related negativity and error positivity produced during an emotional go/no-go challenge, a task activating the rostral anterior cingulate. Twelve elderly patients with major depression, treated with escitalopram 10 mg daily, were studied. Patients who remained symptomatic after 8 weeks of treatment had larger error-related negativity and smaller error positivity amplitude compared with patients who achieved remission. The error-related negativity is elicited during conflict detection and the error positivity reflects the emotional reaction to error. Thus, these findings suggest that two distinct conflict-processing functions of the anterior cingulate are important for antidepressant response of geriatric depression.

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
Issue number3
StatePublished - Feb 2007
Externally publishedYes


  • Depression
  • Electroencephalogram
  • Error-related negativity
  • Event-related potential
  • Geriatric
  • Treatment response

ASJC Scopus subject areas

  • Neuroscience(all)


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